Kinase profiling results of kinases in KIF 2ITXA_ANP (EGFR, PDB code: 2ITX, chain A)
Template Kinase: EGFR
Template inhibitor: Phosphoaminophosphonic Acid-Adenylate Ester

 21 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PDPK1AGC
AURKAOther
NEK7Other
OXSR1STE
STK24STE
ABL1TK
TNK2TK
ALKTK
EGFRTK
ERBB3TK
EPHA3TK
PTK2TK
FGFR1TK
FGFR2TK
IGF1RTK
INSRTK
METTK
RETTK
SRCTK
HCKTK
LCKTK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
PDPK1AGC
AURKAOther
NEK7Other
OXSR1STE
STK24STE
ABL1TK
ALKTK
EGFRTK
EPHA3TK
FGFR1TK
FGFR2TK
HCKTK
IGF1RTK
INSRTK
LCKTK
METTK
PTK2TK
RETTK
SRCTK
TNK2TK