Kinase profiling results of kinases in KIF 2XVDA_AS6 (EPHB4, PDB code: 2XVD, chain A)
Template Kinase: EPHB4
Template inhibitor: {4-Methyl-3-[(1-Methylethyl)(2-{[3-(Methylsulfonyl)-5-Morpholin-4-Ylphenyl]amino} Pyrimidin-4-Yl)amino]phenyl}methanol

 4 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
CSKTK
EPHB4TK
FGFR1TK
KDRTK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
CSKTK
EPHB4TK
FGFR1TK
KDRTK