Kinase profiling results of kinases in KIF 1UV5A_BRW (GSK3B, PDB code: 1UV5, chain A)
Template Kinase: GSK3B
Template inhibitor: 6-bromoindirubin-3-oxime

 27 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PDPK1AGC
RPS6KA1AGC
RPS6KA1CAMK
RPS6KA2AGC
RPS6KA2CAMK
RPS6KA6AGC
RPS6KA6CAMK
CAMK2DCAMK
CAMK2GCAMK
BRSK1CAMK
BRSK2CAMK
STK11CAMK
NUAK1CAMK
SIK2CAMK
PHKG1CAMK
CHEK2CAMK
CDK2CMGC
CDK3CMGC
CDK5CMGC
CDK9CMGC
DYRK2CMGC
GSK3ACMGC
GSK3BCMGC
MAPK10CMGC
AURKAOther
AURKBOther
AURKCOther
EIF2AK2Other

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C
PDPK1AGC   
RPS6KA1AGC   
RPS6KA2AGC   
RPS6KA6AGC   
BRSK1CAMK   
BRSK2CAMK   
CAMK2DCAMK   
CAMK2GCAMK   
CHEK2CAMK   
NUAK1CAMK   
PHKG1CAMK   
SIK2CAMK   
STK11CAMK   
CDC2CMGC   
CDC2CMGC   
CDK2CMGC   
CDK3CMGC   
CDK5CMGC   
CDK6CMGC   
CDK6CMGC   
CDK9CMGC   
DYRK2CMGC   
GSK3ACMGC   
GSK3BCMGC   
MAPK10CMGC   
AURKAOther   
AURKBOther   
AURKCOther