KIDFamMap

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Kinase profiling results of kinases in KIF 2C0IA_L1G (HCK, PDB code: 2C0I, chain A)
Template Kinase: HCK Template inhibitor: A-420983	61 kinases in the family Kinase profiling results source 1. Davis et al. Nature Biotechnology.29, 1046-51 2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45 Similarity between template inhibitor and test compounds of profiling results Atom pair threshold: Checkmol threshold:

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM

>10uM

Kinase	Kinase group	C	C	C	C	C	C	C	C	C	C
RPS6KA1	AGC
RPS6KA1	CAMK
RPS6KA2	AGC
RPS6KA2	CAMK
RPS6KA6	AGC
RPS6KA6	CAMK
CHEK1	CAMK
DAPK1	CAMK
DAPK3	CAMK
CDK2	CMGC
CDK5	CMGC
NLK	CMGC
MAPK14	CMGC
NEK3	Other
NEK2	Other
PLK1	Other
PLK2	Other
PLK3	Other
STK10	STE
ABL1	TK
ABL2	TK
TNK1	TK
TNK2	TK
ALK	TK
LTK	TK
CSK	TK
DDR1	TK
DDR2	TK
EGFR	TK
ERBB2	TK
EPHA8	TK
EPHB1	TK
EPHB2	TK
EPHB6	TK
PTK2	TK
PTK2B	TK
FES	TK
IGF1R	TK
INSR	TK
JAK2	TK
JAK3	TK
MUSK	TK
CSF1R	TK
KIT	TK
PDGFRA	TK
PDGFRB	TK
RET	TK
FRK	TK
FYN	TK
SRC	TK
YES1	TK
BLK	TK
HCK	TK
LCK	TK
LYN	TK
SYK	TK
ITK	TK
NTRK1	TK
NTRK2	TK
NTRK3	TK
IRAK1	TKL
IRAK4	TKL
BRAF	TKL
RAF1	TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%

100%

Kinase	Kinase group	C	C	C	C	C
RPS6KA1	AGC
RPS6KA2	AGC
RPS6KA6	AGC
CHEK1	CAMK
DAPK1	CAMK
DAPK3	CAMK
CDK2	CMGC
CDK5	CMGC
MAPK14	CMGC
NLK	CMGC
NEK2	Other
NEK3	Other
PLK1	Other
PLK2	Other
PLK3	Other
STK10	STE
ABL1	TK
ABL2	TK
ALK	TK
BLK	TK
CSF1R	TK
CSK	TK
DDR2	TK
EGFR	TK
EPHA8	TK
EPHB1	TK
EPHB2	TK
ERBB2	TK
FES	TK
FRK	TK
FYN	TK
HCK	TK
IGF1R	TK
INSR	TK
ITK	TK
JAK2	TK
JAK3	TK
KIT	TK
LCK	TK
LTK	TK
LYN	TK
MUSK	TK
NTRK1	TK
NTRK2	TK
NTRK3	TK
PDGFRA	TK
PDGFRB	TK
PTK2	TK
PTK2B	TK
RET	TK
SRC	TK
SYK	TK
TNK2	TK
YES1	TK
BRAF	TKL
IRAK1	TKL
IRAK4	TKL
RAF1	TKL