Kinase profiling results of kinases in KIF 3E63A_5B2 (JAK2, PDB code: 3E63, chain A)
Template Kinase: JAK2
Template inhibitor: 5-phenyl-1H-indazol-3-amine

15 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PDPK1AGC
DAPK1CAMK
CDK2CMGC
GSK3ACMGC
AURKAOther
AURKBOther
MAP3K5STE
ABL1TK
EGFRTK
JAK2TK
JAK3TK
KITTK
PDGFRBTK
SRCTK
SYKTK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
PDPK1AGC    
DAPK1CAMK    
CDK2CMGC    
GSK3ACMGC    
AURKAOther    
AURKBOther    
MAP3K5STE    
ABL1TK    
EGFRTK    
JAK2TK    
JAK3TK    
KITTK    
PDGFRBTK    
SRCTK    
SYKTK