Kinase profiling results of kinases in KIF 3IO7A_1P5 (JAK2, PDB code: 3IO7, chain A)
Template Kinase: JAK2
Template inhibitor: CP_690550

 24 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
PDPK1AGC 
CDK2CMGC 
CDK4CMGC 
CDK5CMGC 
GSK3ACMGC 
GSK3BCMGC 
AURKAOther 
AURKBOther 
MAP2K1STE 
ABL1TK 
EGFRTK 
IGF1RTK 
INSRTK 
JAK2TK 
JAK3TK 
KITTK 
SRCTK 
HCKTK 
LCKTK 
ITKTK 
NTRK1TK 
BRAFTKL 
RAF1TKL 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
PDPK1AGC 
CDC2CMGC 
CDC2CMGC 
CDK2CMGC 
CDK4CMGC 
CDK5CMGC 
GSK3ACMGC 
GSK3BCMGC 
AURKAOther 
AURKBOther 
MAP2K1STE 
ABL1TK 
EGFRTK 
HCKTK 
IGF1RTK 
INSRTK 
ITKTK 
JAK2TK 
JAK3TK 
KITTK 
LCKTK 
NTRK1TK 
SRCTK 
BRAFTKL 
RAF1TKL