Kinase profiling results of kinases in KIF 2OFVA_242 (LCK, PDB code: 2OFV, chain A)
Template Kinase: LCK
Template inhibitor: 2ofv

28 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C
MAPK14CMGC   
AURKAOther   
AURKCOther   
ABL1TK   
DDR1TK   
EPHA3TK   
EPHA7TK   
FGFR1TK   
INSRTK   
METTK   
MUSKTK   
CSF1RTK   
KITTK   
PDGFRATK   
PDGFRBTK   
SRCTK   
LCKTK   
BMXTK   
TEKTK   
TIE1TK   
NTRK2TK   
NTRK3TK   
FLT1TK   
FLT4TK   
KDRTK   
LIMK2TKL   
BRAFTKL   
RIPK1TKL   

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
MAPK14CMGC    
AURKAOther    
AURKCOther    
ABL1TK    
BMXTK    
CSF1RTK    
EPHA3TK    
EPHA7TK    
FGFR1TK    
FLT1TK    
FLT4TK    
INSRTK    
KDRTK    
KITTK    
LCKTK    
METTK    
MUSKTK    
NTRK2TK    
NTRK3TK    
PDGFRATK    
PDGFRBTK    
SRCTK    
TEKTK    
BRAFTKL