Kinase profiling results of kinases in KIF 2OG8A_1N8 (LCK, PDB code: 2OG8, chain A)
Template Kinase: LCK
Template inhibitor: 1N8

 35 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C C C
MAPK14CMGC       
AURKAOther       
AURKCOther       
ABL1TK       
ABL2TK       
TNK1TK       
DDR1TK       
EPHA1TK       
EPHA3TK       
EPHA7TK       
PTK2BTK       
FGFR1TK       
INSRTK       
METTK       
MUSKTK       
CSF1RTK       
KITTK       
PDGFRATK       
PDGFRBTK       
SRCTK       
YES1TK       
LCKTK       
BMXTK       
BTKTK       
TEKTK       
TIE1TK       
NTRK2TK       
NTRK3TK       
FLT1TK       
FLT4TK       
KDRTK       
LIMK1TKL       
LIMK2TKL       
BRAFTKL       
RIPK1TKL       

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C C C
MAPK14CMGC       
AURKAOther       
AURKCOther       
ABL1TK       
ABL2TK       
BMXTK       
BTKTK       
CSF1RTK       
EPHA1TK       
EPHA3TK       
EPHA7TK       
FGFR1TK       
FLT1TK       
FLT4TK       
INSRTK       
KDRTK       
KITTK       
LCKTK       
METTK       
MUSKTK       
NTRK2TK       
NTRK3TK       
PDGFRATK       
PDGFRBTK       
PTK2BTK       
SRCTK       
TEKTK       
YES1TK       
BRAFTKL       
LIMK1TKL