Kinase profiling results of kinases in KIF 3AC3A_KSH (LCK, PDB code: 3AC3, chain A)
Template Kinase: LCK
Template inhibitor: imidazo[1,2-c]pyrimidine-8-carboxamide, 10b

 13 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C
CDK2CMGC 
CDK5CMGC 
MAPK14CMGC 
AURKAOther 
FGFR1TK 
CSF1RTK 
SRCTK 
LCKTK 
SYKTK 
ZAP70TK 
NTRK1TK 

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
PRKCBAGC 
PRKCBAGC 
CDC2CMGC 
CDC2CMGC 
CDK2CMGC 
CDK5CMGC 
MAPK14CMGC 
AURKAOther 
CSF1RTK 
FGFR1TK 
LCKTK 
NTRK1TK 
SRCTK 
SYKTK 
ZAP70TK