Kinase profiling results of kinases in KIF 3AC5A_KZM (LCK, PDB code: 3AC5, chain A)
Template Kinase: LCK
Template inhibitor: Erlotinib

 11 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
MAPK14CMGC
AURKAOther
ALKTK
CSKTK
IGF1RTK
SRCTK
LCKTK
SYKTK
ZAP70TK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
PRKCBAGC 
PRKCBAGC 
CDC2CMGC 
CDC2CMGC 
MAPK14CMGC 
AURKAOther 
ALKTK 
CSKTK 
IGF1RTK 
LCKTK 
SRCTK 
SYKTK 
ZAP70TK