Kinase profiling results of kinases in KIF 3ACJA_KSS (LCK, PDB code: 3ACJ, chain A)
Template Kinase: LCK
Template inhibitor: 6,7-dimethoxy-3-thiophen-2-yl-quinoline

13 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
NUAK1CAMK
CDK2CMGC
CDK5CMGC
AURKAOther
EGFRTK
CSF1RTK
PDGFRBTK
ROS1TK
YES1TK
LCKTK
PTK6TK
SYKTK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
NUAK1CAMK  
CDC2CMGC  
CDC2CMGC  
CDK2CMGC  
CDK5CMGC  
AURKAOther  
CSF1RTK  
EGFRTK  
LCKTK  
PDGFRBTK  
PTK6TK  
ROS1TK  
SYKTK  
YES1TK