Kinase profiling results of kinases in KIF 3B2WA_9NH (LCK, PDB code: 3B2W, chain A)
Template Kinase: LCK
Template inhibitor: MLS000911569

 30 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C
MAPK14CMGC     
ABL1TK     
TNK2TK     
ALKTK     
EGFRTK     
EPHB1TK     
FGFR1TK     
FGFR2TK     
FGFR3TK     
FGFR4TK     
INSRTK     
JAK2TK     
KITTK     
PDGFRATK     
PDGFRBTK     
RETTK     
ROS1TK     
FYNTK     
SRCTK     
YES1TK     
BLKTK     
HCKTK     
LCKTK     
LYNTK     
SYKTK     
BMXTK     
BTKTK     
NTRK2TK     
BRAFTKL     
RAF1TKL     

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
MAPK14CMGC 
ABL1TK 
ALKTK 
BLKTK 
BMXTK 
BTKTK 
EGFRTK 
EPHB1TK 
FGFR1TK 
FGFR2TK 
FGFR3TK 
FGFR4TK 
FYNTK 
HCKTK 
INSRTK 
JAK2TK 
KITTK 
LCKTK 
LYNTK 
NTRK2TK 
PDGFRATK 
PDGFRBTK 
RETTK 
ROS1TK 
SRCTK 
SYKTK 
TNK2TK 
YES1TK 
BRAFTKL 
RAF1TKL