Kinase profiling results of kinases in KIF 3BYSA_AM5 (LCK, PDB code: 3BYS, chain A)
Template Kinase: LCK
Template inhibitor: Aminopyrimidine amide, 10b

20 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C
MAPK14CMGC   
AURKAOther   
ABL1TK   
EPHA3TK   
EPHA7TK   
FGFR1TK   
INSRTK   
METTK   
CSF1RTK   
KITTK   
PDGFRATK   
PDGFRBTK   
SRCTK   
LCKTK   
BTKTK   
TEKTK   
FLT1TK   
FLT4TK   
KDRTK   
BRAFTKL   

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
MAPK14CMGC    
AURKAOther    
ABL1TK    
BTKTK    
CSF1RTK    
EPHA3TK    
EPHA7TK    
FGFR1TK    
FLT1TK    
FLT4TK    
INSRTK    
KDRTK    
KITTK    
LCKTK    
METTK    
PDGFRATK    
PDGFRBTK    
SRCTK    
TEKTK    
BRAFTKL