Kinase profiling results of kinases in KIF 3BYUA_AM6 (LCK, PDB code: 3BYU, chain A)
Template Kinase: LCK
Template inhibitor: Aminopyrimidine amide, 19

19 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C C C
MAPK14CMGC       
AURKAOther       
ABL1TK       
EPHA3TK       
EPHA7TK       
FGFR1TK       
INSRTK       
METTK       
CSF1RTK       
KITTK       
PDGFRATK       
PDGFRBTK       
SRCTK       
LCKTK       
TEKTK       
FLT1TK       
FLT4TK       
KDRTK       
BRAFTKL       

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C C C
MAPK14CMGC       
AURKAOther       
ABL1TK       
CSF1RTK       
EPHA3TK       
EPHA7TK       
FGFR1TK       
FLT1TK       
FLT4TK       
INSRTK       
KDRTK       
KITTK       
LCKTK       
METTK       
PDGFRATK       
PDGFRBTK       
SRCTK       
TEKTK       
BRAFTKL