Kinase profiling results of kinases in KIF 3FMEA_STU (MAP2K6, PDB code: 3FME, chain A)
Template Kinase: MAP2K6
Template inhibitor: staurosporine

 28 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C
GRK1AGC  
GRK7AGC  
STK17ACAMK  
CDK2CMGC  
CDK3CMGC  
CDK5CMGC  
CDKL1CMGC  
CDKL2CMGC  
CDKL3CMGC  
CDKL5CMGC  
ICKCMGC  
MAKCMGC  
SBK1Other  
MAP3K15STE  
MAP3K5STE  
MAP3K6STE  
MAP3K1STE  
YSK4STE  
MAP3K2STE  
MAP3K3STE  
MAP3K4STE  
STK24STE  
MAP2K3STE  
MAP2K6STE  

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
GRK5AGC    
GRK6AGC    
GRK7AGC    
STK17ACAMK    
CDC2CMGC    
CDC2CMGC    
CDK2CMGC    
CDK3CMGC    
CDK5CMGC    
CDK6CMGC    
CDK6CMGC    
MAP2K6STE    
MAP3K2STE    
MAP3K3STE    
MAP3K5STE    
STK24STE