Kinase profiling results of kinases in KIF 3HECA_STI (MAPK14, PDB code: 3HEC, chain A)
Template Kinase: MAPK14
Template inhibitor: Imatinib

7 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C C C
MAPK9CMGC       
MAPK14CMGC       
ABL1TK       
ABL2TK       
SRCTK       
YES1TK       
LCKTK       

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C C
MAPK14CMGC      
MAPK9CMGC      
ABL1TK      
ABL2TK      
LCKTK      
SRCTK      
YES1TK