Kinase profiling results of kinases in KIF 3O2MA_46A (MAPK8, PDB code: 3O2M, chain A)
Template Kinase: MAPK8
Template inhibitor: tetrazolylypyridine 8d

11 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PRKCDAGC
PRKCQAGC
CDK2CMGC
CDK4CMGC
GSK3BCMGC
MAPK10CMGC
MAPK8CMGC
MAPK11CMGC
AURKAOther
AURKBOther

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
PRKCDAGC  
PRKCQAGC  
CDC2CMGC  
CDC2CMGC  
CDK2CMGC  
CDK4CMGC  
GSK3BCMGC  
MAPK10CMGC  
MAPK11CMGC  
MAPK8CMGC  
AURKAOther  
AURKBOther