Kinase profiling results of kinases in KIF 2JAVA_5Z5 (NEK2, PDB code: 2JAV, chain A)
Template Kinase: NEK2
Template inhibitor: pyrrollylactam indolinone driv. 16g

25 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C
CHEK1CAMK  
MARK1CAMK  
DAPK3CAMK  
PRKD1CAMK  
PRKD2CAMK  
PRKD3CAMK  
CHEK2CAMK  
CDK2CMGC  
CDK3CMGC  
CDC2L6CMGC  
CDK11ACMGC  
CDK11ACMGC  
CDKL2CMGC  
MAPK14CMGC  
ICKCMGC  
MAKCMGC  
CHUKOther  
IKBKEOther  
NEK2Other  
SBK1Other  
PLK2Other  
TTKOther  
SLKSTE  
PTK2BTK  

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C C C
CHEK1CAMK       
CHEK2CAMK       
DAPK3CAMK       
MARK1CAMK       
PRKD1CAMK       
PRKD2CAMK       
PRKD3CAMK       
CDC2CMGC       
CDC2CMGC       
CDK2CMGC       
CDK3CMGC       
CDK6CMGC       
CDK6CMGC       
MAPK14CMGC       
CHUKOther       
IKBKEOther       
NEK2Other       
PLK2Other       
TTKOther       
SLKSTE       
PTK2BTK