Kinase profiling results of kinases in KIF 2XNPA_WCX (NEK2, PDB code: 2XNP, chain A)
Template Kinase: NEK2
Template inhibitor: 4-{5-[(1-Methylpiperidin-4-Yl)oxy]-1h-Benzimidazol-1 -Yl}-2-{(1r)-1-[2-(Trifluoromethyl)phenyl]ethoxy} Benzamide

12 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C C C C C
DAPK3CAMK        
PRKD3CAMK        
CHEK2CAMK        
MAPK14CMGC        
NEK1Other        
NEK5Other        
NEK2Other        
NEK9Other        
PLK1Other        
PLK2Other        
PLK3Other        
SLKSTE        

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
CHEK2CAMK    
DAPK3CAMK    
PRKD3CAMK    
MAPK14CMGC    
NEK1Other    
NEK2Other    
PLK1Other    
PLK2Other    
PLK3Other    
SLKSTE