Kinase profiling results of kinases in KIF 3BGQA_VX2 (PIM1, PDB code: 3BGQ, chain A)
Template Kinase: PIM1
Template inhibitor: triazolopyridazine compound, 1

10 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
RPS6KA2AGC
RPS6KA2CAMK
PIM1CAMK
PIM2CAMK
PIM3CAMK
CDK2CMGC
CDK3CMGC
CDK5CMGC
CSNK2A1CMGC
AURKAOther

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
PRKCAAGC    
RPS6KA2AGC    
PIM1CAMK    
PIM2CAMK    
PIM3CAMK    
CDK2CMGC    
CDK3CMGC    
CDK5CMGC    
CSNK2A1CMGC    
AURKAOther