Kinase profiling results of kinases in KIF 2HOGA_710 (CHEK1, PDB code: 2HOG, chain A)
Template Kinase: CHEK1
Template inhibitor: 3-(Indol-2-yl)indazole 21

 33 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
AKT1AGC
AKT2AGC
PRKCDAGC
PRKCQAGC
PKN1AGC
RPS6KA1AGC
RPS6KA1CAMK
CHEK1CAMK
MARK4CAMK
NUAK1CAMK
SIK2CAMK
STK33CAMK
STK17ACAMK
PHKG1CAMK
PHKG2CAMK
CDK2CMGC
CDK4CMGC
CDK9CMGC
CSNK2A2CMGC
MAPK14CMGC
CAMKK2Other
STK10STE
FYNTK
SRCTK
HCKTK
LYNTK
NTRK2TK
NTRK3TK
BRAFTKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C
AKT1AGC   
AKT2AGC   
PKN1AGC   
PRKCAAGC   
PRKCBAGC   
PRKCBAGC   
PRKCDAGC   
PRKCQAGC   
PRKCZAGC   
RPS6KA1AGC   
CHEK1CAMK   
MARK4CAMK   
NUAK1CAMK   
PHKG1CAMK   
PHKG2CAMK   
SIK2CAMK   
STK17ACAMK   
STK33CAMK   
CDC2CMGC   
CDC2CMGC   
CDK2CMGC   
CDK4CMGC   
CDK6CMGC   
CDK6CMGC   
CDK9CMGC   
CSNK2A2CMGC   
MAPK14CMGC   
CAMKK2Other   
STK10STE   
FYNTK   
HCKTK   
LYNTK   
NTRK2TK   
NTRK3TK   
SRCTK   
BRAFTKL