Kinase profiling results of kinases in KIF 3E5AA_VX6 (AURKA, PDB code: 3E5A, chain A)
Template Kinase: AURKA
Template inhibitor: VX-680

57 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C
AKT2AGC    
GRK4AGC    
PRKCDAGC    
PRKCQAGC    
PKN1AGC    
PKN2AGC    
CHEK1CAMK    
MARK1CAMK    
MARK3CAMK    
DAPK3CAMK    
STK17ACAMK    
MAPKAPK23    
PHKG1CAMK    
PHKG2CAMK    
CDK2CMGC    
CDK5CMGC    
CDK11ACMGC    
CDK11ACMGC    
CDKL2CMGC    
CDKL3CMGC    
CDKL5CMGC    
PRPF4BCMGC    
GSK3BCMGC    
AURKAOther    
AURKBOther    
AURKCOther    
CHUKOther    
NEK5Other    
PLK1Other    
PLK3Other    
PLK4Other    
TLK1Other    
SLKSTE    
STK10STE    
STK24STE    
ABL1TK    
ABL2TK    
TNK1TK    
TNK2TK    
ALKTK    
FGFR1TK    
FGFR2TK    
FGFR3TK    
FGFR4TK    
JAK2TK    
JAK3TK    
RETTK    
BLKTK    
LCKTK    
SYKTK    
BMXTK    
BTKTK    
NTRK1TK    
NTRK2TK    
NTRK3TK    
IRAK4TKL    
RIPK1TKL    

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
AKT2AGC    
GRK4AGC    
PKN1AGC    
PKN2AGC    
PRKCDAGC    
PRKCQAGC    
CHEK1CAMK    
DAPK3CAMK    
MAPKAPK2CAMK    
MARK1CAMK    
MARK3CAMK    
PHKG1CAMK    
PHKG2CAMK    
STK17ACAMK    
CDC2CMGC    
CDC2CMGC    
CDK2CMGC    
CDK5CMGC    
GSK3BCMGC    
AURKAOther    
AURKBOther    
AURKCOther    
CHUKOther    
PLK1Other    
PLK3Other    
SLKSTE    
STK10STE    
STK24STE    
ABL1TK    
ABL2TK    
ALKTK    
BLKTK    
BMXTK    
BTKTK    
FGFR1TK    
FGFR2TK    
FGFR3TK    
FGFR4TK    
JAK2TK    
JAK3TK    
LCKTK    
NTRK1TK    
NTRK2TK    
NTRK3TK    
RETTK    
SYKTK    
TNK2TK    
IRAK4TKL