Kinase profiling results of kinases in KIF 2OU7A_ANP (PLK1, PDB code: 2OU7, chain A)
Template Kinase: PLK1
Template inhibitor: Phosphoaminophosphonic Acid-Adenylate Ester

 22 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PDPK1AGC
PRKCIAGC
CASKCAMK
DAPK1CAMK
MAPKAPK23
CHEK2CAMK
CDK2CMGC
GSK3BCMGC
MAPK12CMGC
AURKAOther
NEK2Other
EIF2AK2Other
PLK1Other
PLK4Other
STK24STE
PTK2TK
FGFR1TK
FGFR2TK
INSRTK
HCKTK
IRAK4TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
GRK6AGC
PDPK1AGC
PRKCIAGC
CHEK2CAMK
DAPK1CAMK
MAPKAPK2CAMK
CDK2CMGC
GSK3BCMGC
MAPK12CMGC
AURKAOther
NEK2Other
PLK1Other
STK24STE
FGFR1TK
FGFR2TK
HCKTK
INSRTK
PTK2TK
IRAK4TKL