Kinase profiling results of kinases in KIF 2OWBA_626 (PLK1, PDB code: 2OWB, chain A)
Template Kinase: PLK1
Template inhibitor: 2j4z

10 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C C
MAPKAPK23    
CDK2CMGC    
GSK3ACMGC    
GSK3BCMGC    
MAPK14CMGC    
AURKAOther    
AURKBOther    
PLK1Other    
INSRTK    
HCKTK    

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
MAPKAPK2CAMK    
CDK2CMGC    
GSK3ACMGC    
GSK3BCMGC    
MAPK14CMGC    
AURKAOther    
AURKBOther    
PLK1Other    
HCKTK    
INSRTK