Kinase profiling results of kinases in KIF 2YACA_937 (PLK1, PDB code: 2YAC, chain A)
Template Kinase: PLK1
Template inhibitor: 1-(2-Hydroxyethyl)-8-[[5-(4-Methylpiperazin-1-Yl)-2-(Trifluoromethoxy)phenyl]amino]-4,5-Dihydropyrimido[5,4-G]indazole-3-Carboxamide

 7 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C
CDK2CMGC  
AURKAOther  
AURKBOther  
PLK1Other  
PLK2Other  
PLK3Other  
INSRTK  

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
CDK2CMGC 
AURKAOther 
AURKBOther 
PLK1Other 
PLK2Other 
PLK3Other 
INSRTK