KIDFamMap

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Kinase profiling results of kinases in KIF 1OKZA_UCN (PDPK1, PDB code: 1OKZ, chain A)
Template Kinase: PDPK1 Template inhibitor: UCN 02	178 kinases in the family Kinase profiling results source 1. Davis et al. Nature Biotechnology.29, 1046-51 2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45 Similarity between template inhibitor and test compounds of profiling results Atom pair threshold: Checkmol threshold:

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM

>10uM

Kinase	Kinase group	C	C
AKT1	AGC
AKT2	AGC
AKT3	AGC
GRK1	AGC
GRK4	AGC
GRK7	AGC
PDPK1	AGC
PRKACA	AGC
PRKACB	AGC
PRKX	AGC
PRKCD	AGC
PRKCQ	AGC
PRKCH	AGC
PRKCI	AGC
PRKG1	AGC
PRKG2	AGC
PKN2	AGC
RPS6KB1	AGC
RPS6KA1	AGC
RPS6KA1	CAMK
RPS6KA2	AGC
RPS6KA2	CAMK
RPS6KA3	AGC
RPS6KA6	AGC
RPS6KA6	CAMK
STK32A	AGC
STK32B	AGC
STK32C	AGC
CAMK1G	CAMK
CAMK2A	CAMK
CAMK2B	CAMK
CAMK2D	CAMK
PRKAA1	CAMK
PRKAA2	CAMK
BRSK1	CAMK
BRSK2	CAMK
CHEK1	CAMK
HUNK	CAMK
STK11	CAMK
MARK2	CAMK
MARK4	CAMK
MELK	CAMK
MGC42105	3
NUAK1	CAMK
NUAK2	CAMK
KIAA0999	CAMK
SIK1	CAMK
SIK2	CAMK
SNRK	CAMK
STK33	CAMK
DAPK1	CAMK
DAPK2	CAMK
DAPK3	CAMK
STK17A	CAMK
STK17B	CAMK
MAPKAPK2	3
MAPKAPK5	3
PHKG1	CAMK
PHKG2	CAMK
PIM1	CAMK
PIM2	CAMK
PIM3	CAMK
PRKD1	CAMK
PRKD2	CAMK
PRKD3	CAMK
CHEK2	CAMK
TSSK1B	CAMK
CDK2	CMGC
CDK3	CMGC
CDK4	CMGC
CDK5	CMGC
CDK7	CMGC
CDC2L6	CMGC
CDK8	CMGC
CDC2L5	CMGC
PCTK1	CMGC
PCTK2	CMGC
PCTK3	CMGC
CDK15	CMGC
PFTK1	CMGC
CDKL1	CMGC
CDKL2	CMGC
CDKL3	CMGC
CDKL5	CMGC
CSNK2A1	CMGC
CSNK2A2	CMGC
DYRK1A	CMGC
DYRK1B	CMGC
DYRK2	CMGC
HIPK1	CMGC
HIPK2	CMGC
HIPK3	CMGC
HIPK4	CMGC
PRPF4B	CMGC
GSK3A	CMGC
GSK3B	CMGC
MAPK1	CMGC
MAPK3	CMGC
MAPK7	CMGC
MAPK15	CMGC
MAPK10	CMGC
MAPK8	CMGC
MAPK9	CMGC
MAPK12	CMGC
MAPK13	CMGC
MAPK14	CMGC
ICK	CMGC
MAK	CMGC
AURKA	Other
AURKB	Other
AURKC	Other
GAK	Other
NEK1	Other
NEK5	Other
NEK2	Other
NEK4	Other
NEK9	Other
SBK1	Other
EIF2AK4	Other
EIF2AK2	Other
PLK1	Other
PLK2	Other
PLK3	Other
PLK4	Other
TLK1	Other
TLK2	Other
TTK	Other
STK36	Other
ULK1	Other
ULK2	Other
ULK3	Other
MAP3K15	STE
MAP3K5	STE
MAP3K6	STE
MAP3K1	STE
YSK4	STE
MAP3K2	STE
MAP3K3	STE
MAP3K4	STE
OXSR1	STE
STK39	STE
PAK1	STE
PAK2	STE
PAK3	STE
PAK4	STE
PAK6	STE
PAK7	STE
SLK	STE
STK24	STE
ABL1	TK
ABL2	TK
CSK	TK
MATK	TK
EGFR	TK
ERBB4	TK
EPHA3	TK
EPHA4	TK
EPHA5	TK
EPHB1	TK
FGFR2	TK
JAK2	TK
JAK3	TK
RET	TK
LYN	TK
BMX	TK
BTK	TK
TEC	TK
TXK	TK
IRAK4	TKL
LIMK1	TKL
LIMK2	TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%

100%

Kinase	Kinase group	C	C	C
AKT1	AGC
AKT2	AGC
AKT3	AGC
GRK4	AGC
GRK5	AGC
GRK6	AGC
GRK7	AGC
PDPK1	AGC
PKN2	AGC
PRKACA	AGC
PRKACG	AGC
PRKCB	AGC
PRKCB	AGC
PRKCD	AGC
PRKCH	AGC
PRKCI	AGC
PRKCQ	AGC
PRKCZ	AGC
PRKG1	AGC
PRKG2	AGC
PRKX	AGC
RPS6KA1	AGC
RPS6KA2	AGC
RPS6KA3	AGC
RPS6KA6	AGC
RPS6KB1	AGC
RPS6KB2	AGC
BRSK1	CAMK
BRSK2	CAMK
CAMK1G	CAMK
CAMK2A	CAMK
CAMK2B	CAMK
CAMK2D	CAMK
CHEK1	CAMK
CHEK2	CAMK
DAPK1	CAMK
DAPK2	CAMK
DAPK3	CAMK
MAPKAPK2	CAMK
MAPKAPK5	CAMK
MARK2	CAMK
MARK4	CAMK
MELK	CAMK
NUAK1	CAMK
NUAK2	CAMK
PHKG1	CAMK
PHKG2	CAMK
PIM1	CAMK
PIM2	CAMK
PIM3	CAMK
PRKD1	CAMK
PRKD2	CAMK
PRKD3	CAMK
SIK2	CAMK
STK11	CAMK
STK17A	CAMK
STK33	CAMK
TSSK1B	CAMK
TSSK2	CAMK
CDC2	CMGC
CDC2	CMGC
CDK2	CMGC
CDK3	CMGC
CDK4	CMGC
CDK5	CMGC
CDK6	CMGC
CDK6	CMGC
CDK7	CMGC
CSNK2A1	CMGC
CSNK2A2	CMGC
DYRK1A	CMGC
DYRK1B	CMGC
DYRK2	CMGC
GSK3A	CMGC
GSK3B	CMGC
HIPK1	CMGC
HIPK2	CMGC
HIPK3	CMGC
HIPK4	CMGC
MAPK1	CMGC
MAPK10	CMGC
MAPK12	CMGC
MAPK13	CMGC
MAPK14	CMGC
MAPK3	CMGC
MAPK8	CMGC
MAPK9	CMGC
AURKA	Other
AURKB	Other
AURKC	Other
NEK1	Other
NEK2	Other
NEK4	Other
NEK8	Other
PLK1	Other
PLK2	Other
PLK3	Other
TLK2	Other
TTK	Other
ULK1	Other
ULK2	Other
ULK3	Other
MAP3K2	STE
MAP3K3	STE
MAP3K5	STE
OXSR1	STE
PAK1	STE
PAK2	STE
PAK3	STE
PAK4	STE
PAK6	STE
PAK7	STE
SLK	STE
STK24	STE
STK39	STE
ABL1	TK
ABL2	TK
BMX	TK
BTK	TK
CSK	TK
EGFR	TK
EPHA3	TK
EPHA4	TK
EPHA5	TK
EPHB1	TK
ERBB4	TK
FGFR2	TK
JAK2	TK
JAK3	TK
LYN	TK
MATK	TK
RET	TK
TEC	TK
TXK	TK
IRAK4	TKL
LIMK1	TKL