Kinase profiling results of kinases in KIF 3FZTA_4JZ (PTK2B, PDB code: 3FZT, chain A)
Template Kinase: PTK2B
Template inhibitor: PF-4618433

9 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C C
ABL1TK   
PTK2BTK   
LCKTK   
TEKTK   
TIE1TK   
FLT1TK   
FLT4TK   
KDRTK   
BRAFTKL   

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C
ABL1TK  
FLT1TK  
FLT4TK  
KDRTK  
LCKTK  
PTK2BTK  
TEKTK  
BRAFTKL