Kinase profiling results of kinases in KIF 2IVTA_AMP (RET, PDB code: 2IVT, chain A)
Template Kinase: RET
Template inhibitor: Adenosine monophosphate

 25 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
AKT2AGC
PDPK1AGC
AURKAOther
OXSR1STE
STK24STE
ABL1TK
TNK2TK
ALKTK
MERTKTK
EGFRTK
EPHA3TK
PTK2TK
FGFR2TK
IGF1RTK
INSRTK
METTK
MST1RTK
KITTK
RETTK
SRCTK
HCKTK
LCKTK
ZAP70TK
IRAK4TKL
MAP3K7TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
AKT2AGC 
PDPK1AGC 
AURKAOther 
OXSR1STE 
STK24STE 
ABL1TK 
ALKTK 
EGFRTK 
EPHA3TK 
FGFR2TK 
HCKTK 
IGF1RTK 
INSRTK 
KITTK 
LCKTK 
MERTKTK 
METTK 
MST1RTK 
PTK2TK 
RETTK 
SRCTK 
TNK2TK 
ZAP70TK 
IRAK4TKL 
MAP3K7TKL