Kinase profiling results of kinases in KIF 1UKIA_537 (MAPK8, PDB code: 1UKI, chain A)
Template Kinase: MAPK8
Template inhibitor: 1,9-Pyrazoloanthrone

 20 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
RPS6KA2AGC
RPS6KA2CAMK
CAMK1GCAMK
STK33CAMK
DAPK2CAMK
PRKD1CAMK
PRKD2CAMK
PRKD3CAMK
CHEK2CAMK
CDK2CMGC
CLK2CMGC
CLK3CMGC
DYRK2CMGC
MAPK10CMGC
MAPK8CMGC
MAPK9CMGC
MAPK12CMGC
AURKAOther
AURKBOther
AURKCOther
CAMKK2Other

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C C
RPS6KA2AGC      
CAMK1GCAMK      
CHEK2CAMK      
DAPK2CAMK      
PRKD1CAMK      
PRKD2CAMK      
PRKD3CAMK      
STK33CAMK      
CDK2CMGC      
CLK2CMGC      
CLK3CMGC      
DYRK2CMGC      
MAPK10CMGC      
MAPK12CMGC      
MAPK8CMGC      
MAPK9CMGC      
AURKAOther      
AURKBOther      
AURKCOther      
CAMKK2Other