Kinase profiling results of kinases in KIF 1UNLA_RRC (CDK5, PDB code: 1UNL, chain A)
Template Kinase: CDK5
Template inhibitor: roscovitine

 45 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
RPS6KA1AGC
RPS6KA1CAMK
RPS6KA2AGC
RPS6KA2CAMK
RPS6KA6AGC
RPS6KA6CAMK
CHEK1CAMK
DAPK1CAMK
CHEK2CAMK
CDK2CMGC
CDK3CMGC
CDK4CMGC
CDK5CMGC
CDK9CMGC
PCTK1CMGC
CLK1CMGC
CLK2CMGC
CLK4CMGC
DYRK1ACMGC
DYRK1BCMGC
GSK3BCMGC
MAPK1CMGC
MAPK3CMGC
MAPK15CMGC
MAPK10CMGC
MAPK8CMGC
MAPK14CMGC
AURKAOther
AURKBOther
CHUKOther
PLK1Other
PLK3Other
TTKOther
SLKSTE
ABL1TK
ABL2TK
JAK2TK
MUSKTK
FGRTK
FYNTK
SRCTK
YES1TK
HCKTK
LCKTK
LYNTK
TXKTK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
RPS6KA1AGC     
RPS6KA2AGC     
RPS6KA6AGC     
CHEK1CAMK     
CHEK2CAMK     
DAPK1CAMK     
CDC2CMGC     
CDC2CMGC     
CDK2CMGC     
CDK3CMGC     
CDK4CMGC     
CDK5CMGC     
CDK6CMGC     
CDK6CMGC     
CDK9CMGC     
CLK1CMGC     
CLK2CMGC     
CLK4CMGC     
DYRK1ACMGC     
DYRK1BCMGC     
GSK3BCMGC     
MAPK1CMGC     
MAPK10CMGC     
MAPK14CMGC     
MAPK3CMGC     
MAPK8CMGC     
AURKAOther     
AURKBOther     
CHUKOther     
PLK1Other     
PLK3Other     
TTKOther     
SLKSTE     
ABL1TK     
ABL2TK     
FGRTK     
FYNTK     
HCKTK     
JAK2TK     
LCKTK     
LYNTK     
MUSKTK     
SRCTK     
TXKTK     
YES1TK