Kinase profiling results of kinases in KIF 2BRMA_DFZ (CHEK1, PDB code: 2BRM, chain A)
Template Kinase: CHEK1
Template inhibitor: DFZ

21 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PRKCDAGC
RPS6KA2AGC
RPS6KA2CAMK
CHEK1CAMK
PIM1CAMK
CHEK2CAMK
CDK2CMGC
CDK4CMGC
CDK5CMGC
CDK9CMGC
PCTK1CMGC
MAPK1CMGC
MAPK14CMGC
AURKAOther
CHUKOther
PLK1Other
PLK3Other
PAK4STE
SRCTK
NTRK3TK

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C C
PRKCAAGC     
PRKCDAGC     
RPS6KA2AGC     
CHEK1CAMK     
CHEK2CAMK     
PIM1CAMK     
CDC2CMGC     
CDC2CMGC     
CDK2CMGC     
CDK4CMGC     
CDK5CMGC     
CDK9CMGC     
MAPK1CMGC     
MAPK14CMGC     
AURKAOther     
CHUKOther     
PLK1Other     
PLK3Other     
PAK4STE     
NTRK3TK     
SRCTK