Kinase profiling results of kinases in KIF 2X2KA_X2K (RET, PDB code: 2X2K, chain A)
Template Kinase: RET
Template inhibitor: Semaxanib

23 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group
PDPK1AGC
RPS6KA1AGC
RPS6KA1CAMK
RPS6KA2AGC
RPS6KA2CAMK
RPS6KA6AGC
RPS6KA6CAMK
ALKTK
LTKTK
PTK2TK
FGFR1TK
JAK2TK
JAK3TK
CSF1RTK
KITTK
PDGFRBTK
RETTK
SRCTK
NTRK1TK
NTRK2TK
NTRK3TK
IRAK4TKL
LRRK2TKL
MAP3K11TKL
MAP3K9TKL
RAF1TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C C
PDPK1AGC    
RPS6KA1AGC    
RPS6KA2AGC    
RPS6KA6AGC    
ALKTK    
CSF1RTK    
FGFR1TK    
JAK2TK    
JAK3TK    
KITTK    
LTKTK    
NTRK1TK    
NTRK2TK    
NTRK3TK    
PDGFRBTK    
PTK2TK    
RETTK    
SRCTK    
IRAK4TKL    
LRRK2TKL    
MAP3K11TKL    
MAP3K9TKL    
RAF1TKL