KIDFamMap

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Kinase profiling results of kinases in KIF 3LW0A_CCX (IGF1R, PDB code: 3LW0, chain A)
Template Kinase: IGF1R Template inhibitor: 5-vinyl-3-pyridinecarbonitrile, 28	53 kinases in the family Kinase profiling results source 1. Davis et al. Nature Biotechnology.29, 1046-51 2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45 Similarity between template inhibitor and test compounds of profiling results Atom pair threshold: Checkmol threshold:

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM

>10uM

Kinase	Kinase group	C	C	C	C	C	C	C
RPS6KA1	AGC
RPS6KA1	CAMK
RPS6KA2	AGC
RPS6KA2	CAMK
RPS6KA3	AGC
SLK	STE
STK24	STE
ABL1	TK
ALK	TK
AXL	TK
MERTK	TK
DDR1	TK
DDR2	TK
EGFR	TK
EPHA1	TK
EPHA3	TK
EPHA4	TK
EPHA5	TK
EPHA6	TK
EPHB1	TK
EPHB2	TK
EPHB4	TK
EPHB6	TK
PTK2	TK
PTK2B	TK
FER	TK
FES	TK
FGFR1	TK
FGFR2	TK
FGFR3	TK
IGF1R	TK
INSR	TK
INSRR	TK
JAK2	TK
TYK2	TK
MUSK	TK
RET	TK
ROS1	TK
SRC	TK
YES1	TK
BLK	TK
HCK	TK
LCK	TK
BMX	TK
BTK	TK
ITK	TK
TEC	TK
TXK	TK
TEK	TK
NTRK1	TK
NTRK2	TK
NTRK3	TK
FLT4	TK
KDR	TK
RIPK1	TKL

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%

100%

Kinase	Kinase group	C	C	C	C	C	C	C
RPS6KA1	AGC
RPS6KA2	AGC
RPS6KA3	AGC
SLK	STE
STK24	STE
ABL1	TK
ALK	TK
AXL	TK
BLK	TK
BMX	TK
BTK	TK
DDR2	TK
EGFR	TK
EPHA1	TK
EPHA3	TK
EPHA4	TK
EPHA5	TK
EPHA6	TK
EPHB1	TK
EPHB2	TK
EPHB4	TK
FER	TK
FES	TK
FGFR1	TK
FGFR2	TK
FGFR3	TK
FLT4	TK
HCK	TK
IGF1R	TK
INSR	TK
INSRR	TK
ITK	TK
JAK2	TK
KDR	TK
LCK	TK
MERTK	TK
MUSK	TK
NTRK1	TK
NTRK2	TK
NTRK3	TK
PTK2	TK
PTK2B	TK
RET	TK
ROS1	TK
SRC	TK
TEC	TK
TEK	TK
TXK	TK
TYK2	TK
YES1	TK