Kinase profiling results of kinases in KIF 3PA5A_C73 (CHEK1, PDB code: 3PA5, chain A)
Template Kinase: CHEK1
Template inhibitor: 2-(Carbamoylamino)-5-(4-Chlorophenyl)-N-[(3s)-Piperidin-3-Yl]thiophene-3-Carboxamide

15 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C
RPS6KB1AGC  
RPS6KA2AGC  
RPS6KA2CAMK  
RPS6KA6AGC  
RPS6KA6CAMK  
CHEK1CAMK  
NUAK1CAMK  
CHEK2CAMK  
AURKAOther  
AURKBOther  
AURKCOther  
EIF2AK2Other  
JAK1TK  
NTRK1TK  
NTRK2TK  
NTRK3TK  
LIMK1TKL  

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C C C
RPS6KA2AGC   
RPS6KA6AGC   
RPS6KB1AGC   
CHEK1CAMK   
CHEK2CAMK   
NUAK1CAMK   
AURKAOther   
AURKBOther   
AURKCOther   
JAK1TK   
NTRK1TK   
NTRK2TK   
NTRK3TK   
LIMK1TKL