Kinase profiling results of kinases in KIF 3EQRA_T74 (TNK2, PDB code: 3EQR, chain A)
Template Kinase: TNK2
Template inhibitor: T74

 34 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C
PRKCDAGC  
PRKCQAGC  
CDK2CMGC  
AURKAOther  
ABL1TK  
TNK1TK  
TNK2TK  
ALKTK  
CSKTK  
EGFRTK  
ERBB2TK  
EPHB4TK  
FGFR1TK  
INSRTK  
JAK2TK  
JAK3TK  
METTK  
KITTK  
PDGFRBTK  
RETTK  
FYNTK  
SRCTK  
YES1TK  
BLKTK  
LCKTK  
LYNTK  
SYKTK  
ZAP70TK  
BTKTK  
ITKTK  
TEKTK  
IRAK4TKL  
RAF1TKL  

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group C
PRKCDAGC 
PRKCQAGC 
CDC2CMGC 
CDC2CMGC 
CDK2CMGC 
AURKAOther 
ABL1TK 
ALKTK 
BLKTK 
BTKTK 
CSKTK 
EGFRTK 
EPHB4TK 
ERBB2TK 
FGFR1TK 
FYNTK 
INSRTK 
ITKTK 
JAK2TK 
JAK3TK 
KITTK 
LCKTK 
LYNTK 
METTK 
PDGFRBTK 
RETTK 
SRCTK 
SYKTK 
TEKTK 
TNK2TK 
YES1TK 
ZAP70TK 
IRAK4TKL 
RAF1TKL