Kinase profiling results of kinases in KIF 3GFWA_S22 (TTK, PDB code: 3GFW, chain A)
Template Kinase: TTK
Template inhibitor: 1-(4-(4-(2-(Isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol

 21 kinases in the family
Kinase profiling results source
1. Davis et al. Nature Biotechnology.29, 1046-51
2. Anastassiadis, T. et al. Nature Biotechnology.29, 1039-45


Similarity between template inhibitor and test compounds of profiling results

Davis et al.
Nature Biotechnology.29, 1046-51

<1nM    >10uM
KinaseKinase group C C
RPS6KA1AGC  
RPS6KA1CAMK  
RPS6KA2AGC  
RPS6KA2CAMK  
RPS6KA3AGC  
RPS6KA6AGC  
RPS6KA6CAMK  
CAMK1GCAMK  
STK33CAMK  
DAPK1CAMK  
DAPK3CAMK  
PHKG1CAMK  
PHKG2CAMK  
CDK2CMGC  
CDK5CMGC  
CDKL5CMGC  
NEK1Other  
NEK3Other  
NEK5Other  
NEK2Other  
NEK4Other  
TTKOther  
ULK3Other  
STK24STE  

Anastassiadis, T. et al.
Nature Biotechnology.29, 1039-45

0%    100%
KinaseKinase group
RPS6KA1AGC
RPS6KA2AGC
RPS6KA3AGC
RPS6KA6AGC
CAMK1GCAMK
DAPK1CAMK
DAPK3CAMK
PHKG1CAMK
PHKG2CAMK
STK33CAMK
CDK2CMGC
CDK5CMGC
NEK1Other
NEK2Other
NEK3Other
NEK4Other
TTKOther
ULK3Other
STK24STE