KIDFamMap

Allelic Variants
There are no related allelic variants

Related diseases of KIF 2PE2A_464 (PDB code: 2PE2, chain A)
Number of involved diseases in the family	104
Number of PDPK1 related diseases	1

All kinase in this family PDPK1

Allelic Variants	Disease Description	Involved kinases (This family)	Inhibitor of Involved Kinases	Search Disease
n/a	Epstein-Barr virus infection	AKT1, AKT2, CDC2, CDK2, CSNK2A1, CSNK2A2, EIF2AK2, EIF2AK4, GSK3B, JAK3, LYN, MAPK10, MAPK14, MAPK8, MAPK9, RIPK1	81	Link
n/a	Measles	AKT1, AKT2, CDK2, CDK4, CDK6, CSNK2A1, CSNK2A2, EIF2AK2, EIF2AK4, GSK3B, IRAK4, JAK2, JAK3, PRKCQ	40	Link
n/a	Influenza A	AKT1, AKT2, EIF2AK2, EIF2AK4, GSK3B, IRAK4, JAK2, MAPK10, MAPK14, MAPK8, MAPK9, PRKCB	61	Link
n/a	Hepatitis C	AKT1, AKT2, BRAF, EGFR, EIF2AK2, EIF2AK4, GSK3B, MAPK10, MAPK14, MAPK8, MAPK9, RIPK1	55	Link
n/a	Tuberculosis	AKT1, AKT2, CAMK2A, CAMK2B, CAMK2D, IRAK4, JAK2, MAPK10, MAPK14, MAPK8, MAPK9	55	Link
	Leukemia	ABL1, ABL2, AKT1, AKT2, BRAF, CDK4, CDK6, JAK2, PIM2, RPS6KB1	22	Link
n/a	Herpes simplex infection	CDC2, CDK2, CSNK2A1, CSNK2A2, EIF2AK2, EIF2AK4, JAK2, MAPK10, MAPK8, MAPK9	27	Link
	Prostate cancer	AKT1, AKT2, BRAF, CDK2, CHEK2, EGFR, FGFR2, GSK3B, PDPK1	43	Link
n/a	Toxoplasmosis	AKT1, AKT2, IRAK4, JAK2, MAPK10, MAPK14, MAPK8, MAPK9	53	Link
	Lung cancer	AKT1, AKT2, BRAF, CDK2, CDK4, CDK6, EGFR	31	Link
	Melanoma	AKT1, AKT2, BRAF, CDK4, CDK6, EGFR, STK11	17	Link
n/a	Chagas disease	AKT1, AKT2, IRAK4, MAPK10, MAPK14, MAPK8, MAPK9	49	Link
	Diabetes mellitus	AKT2, MAPK10, MAPK8, MAPK9, PRKCD, PRKCZ	10	Link
n/a	Epithelial cell signaling in Helicobacter pylori infection	EGFR, LYN, MAPK10, MAPK14, MAPK8, MAPK9	55	Link
n/a	Shigellosis	ABL1, MAPK10, MAPK14, MAPK8, MAPK9	51	Link
n/a	Pertussis	IRAK4, MAPK10, MAPK14, MAPK8, MAPK9	47	Link
n/a	Salmonella infection	MAPK10, MAPK14, MAPK8, MAPK9, PKN2	46	Link
n/a	Leishmaniasis	IRAK4, JAK2, MAPK14, PRKCB	58	Link
	Mental retardation	DYRK1A, PAK3, RPS6KA3	5	Link
n/a	Thyroid cancer	BRAF, RET	9	Link
	Adenocarcinoma of lung	BRAF, EGFR	7	Link
n/a	Glioma	CDK4, EGFR	13	Link
n/a	Cervical cancer	CDK4, EGFR	13	Link
n/a	Bladder cancer	DAPK1, EGFR	6	Link
	Gastric cancer	EGFR, FGFR2	7	Link
n/a	Malignant melanoma	BRAF, CDK4	11	Link
	Ovarian cancer	AKT1, AKT2	3	Link
	Colorectal cancer	AKT1, BRAF	3	Link
	Breast cancer	AKT1, CHEK2	5	Link
n/a	Viral myocarditis	ABL1, ABL2	8	Link
n/a	Cardiomyopathy	PRKAA1, PRKAA2	3	Link
n/a	Non-syndromic X-linked mental retardation	PAK3, RPS6KA3	5	Link
	Li-Fraumeni syndrome	CHEK2	4	Link
n/a	PTEN hamartoma tumor syndrome	AKT1	1	Link
n/a	Familial partial lipodystrophy	AKT2	3	Link
	Osteosarcoma	CHEK2	4	Link
n/a	Oral cancer	EGFR	5	Link
n/a	Esophageal cancer	EGFR	5	Link
n/a	Laryngeal cancer	EGFR	5	Link
n/a	Pathogenic Escherichia coli infection	ABL1	8	Link
n/a	Choriocarcinoma	EGFR	5	Link
	Hypoinsulinemic hypoglycemia	AKT2	3	Link
n/a	Cocaine addiction	CDK5	4	Link
n/a	Noonan syndrome and related disorders	BRAF	2	Link
n/a	Agammaglobulinemias	BTK	3	Link
	Noonan syndrome	BRAF	2	Link
	LEOPARD syndrome	BRAF	2	Link
	Cardiofaciocutaneous syndrome	BRAF	2	Link
n/a	Schizophrenia	AKT1	1	Link
n/a	Proteus syndrome	AKT1	1	Link
n/a	Alcoholism	BRAF	2	Link
	Colon cancer	AURKA	40	Link
n/a	Agammaglobulinemia and isolated hormone deficiency	BTK	3	Link
n/a	Pituitary Dwarfism	BTK	3	Link
	Agammaglobulinemia	BTK	3	Link
	Apert syndrome	FGFR2	4	Link
n/a	Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis	FGFR2	4	Link
n/a	African trypanosomiasis	PRKCB	6	Link
n/a	Amoebiasis	PRKCB	6	Link
n/a	Cerebral infarction	PRKCH	3	Link
n/a	Type I diabetes mellitus	PRKCQ	6	Link
n/a	Vibrio cholerae infection	PRKCB	6	Link
	Glycogen storage disease	PHKG2	6	Link
n/a	Epileptic encephalopathy	MAPK10	2	Link
n/a	Amyotrophic lateral sclerosis	MAPK14	43	Link
n/a	Glycogen storage diseases	PHKG2	6	Link
n/a	Cirrhosis due to liver phosphorylase kinase deficiency	PHKG2	6	Link
n/a	Renal agenesis and Renal adysplasia	RET	7	Link
	Hirschsprung disease	RET	7	Link
n/a	Coffin-Lowry syndrome	RPS6KA3	5	Link
n/a	Pancreatic cancer	STK11	3	Link
n/a	Peutz-Jeghers syndrome	STK11	3	Link
n/a	Testicular tumor	STK11	3	Link
	Renal agenesis	RET	7	Link
	Pheochromocytoma	RET	7	Link
n/a	Congenital central hypoventilation syndrome	RET	7	Link
	Central hypoventilation syndrome	RET	7	Link
n/a	Medullary thyroid carcinoma	RET	7	Link
	Multiple endocrine neoplasia	RET	7	Link
n/a	Early infantile epileptic encephalopathy	MAPK10	2	Link
	SCID	JAK3	10	Link
	LADD syndrome	FGFR2	4	Link
	Pfeiffer syndrome	FGFR2	4	Link
n/a	Saethre-Chotzen syndrome	FGFR2	4	Link
	Scaphocephaly	FGFR2	4	Link
	Jackson-Weiss syndrome	FGFR2	4	Link
	Crouzon syndrome	FGFR2	4	Link
	Beare-Stevenson cutis gyrata syndrome	FGFR2	4	Link
	Bent bone dysplasia syndrome	FGFR2	4	Link
	Craniofacial-skeletal-dermatologic dysplasia	FGFR2	4	Link
	Craniosynostosis	FGFR2	4	Link
n/a	Scaphocephaly and Axenfeld-Rieger anomaly	FGFR2	4	Link
n/a	Congenital stationary night blindness	GRK1	3	Link
	Myelofibrosis	JAK2	7	Link
n/a	Myeloproliferative disorder	JAK2	7	Link
	Thrombocythemia	JAK2	7	Link
n/a	Immunodeficiencies	JAK3	10	Link
n/a	Budd-Chiari syndrome	JAK2	7	Link
	Polycythemia vera	JAK2	7	Link
n/a	Oguchi disease	GRK1	3	Link
n/a	Basal cell carcinoma	GSK3B	4	Link
n/a	Endocrine-cerebroosteodysplasia	ICK	3	Link
	IRAK4 deficiency	IRAK4	4	Link
n/a	Invasive pneumococcal disease	IRAK4	4	Link

BioXGEM.

KIDFamMap

Allelic Variants