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Example2
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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
6 CHEK2 related diseases
H00881
Li-Fraumeni syndrome
OMIM
(604373)
{Breast and colorectal cancer, susceptibility to}
114480
{Breast cancer, susceptibility to}
609265
Li-Fraumeni syndrome
259500
Osteosarcoma, somatic
176807
{Prostate cancer, familial, susceptibility to}
Summary of query kinase
Query kinase
CHEK2 (
O96017
)
Kinase group
CAMK
Number of conformation types
2
Number of structural templates
12 (
Total 276 inhibitors
)
Number of CHEK2 related diseases
6 (
H00881
OMIM:604373
114480
609265
259500
176807
)
Number of allelic variants
10 (
A17S
E239K
E239X
I157T
P85L
R145W
R180H
R181C
R181H
S428F
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
4
2XM8A_B4W
(CHEK2)
CAMK
PI_103
I
12
54
18
A
2XM8A_B4W
(CHEK2)
CAMK
PI_103
I
12
54
18
12
54
18
A
2CN8A_DBQ
(CHEK2)
CAMK
Debromohymen...
I
11
33
29
11
33
29
A
2XBJA_XBJ
(CHEK2)
CAMK
4-Fluoro-2-(...
I
2
24
4
2
24
4
A
2W7XA_D1A
(CHEK2)
CAMK
BIBF_1120der
I
1
2
4
1
2
4
B
8
2CN5A_ADP
(CHEK2)
CAMK
Adenosine-5'...
I
16
6
30
B
2CN5A_ADP
(CHEK2)
CAMK
Adenosine-5'...
I
16
6
30
16
6
30
B
2WTCA_VGM
(CHEK2)
CAMK
VGM
I
10
39
19
10
39
19
B
2XM9A_LWH
(CHEK2)
CAMK
4-(1h-Pyrazo...
I
5
34
17
5
34
17
B
2WTDA_ZZK
(CHEK2)
CAMK
ZZK
I
4
27
4
4
27
4
B
2WTIA_WTI
(CHEK2)
CAMK
WTI
I
4
20
6
4
20
6
B
2WTJA_WTJ
(CHEK2)
CAMK
WTJ
I
2
3
4
2
3
4
B
2XK9A_XK9
(CHEK2)
CAMK
Indolinone b...
I
1
2
4
1
2
4
B
2W0JA_ZAT
(CHEK2)
CAMK
DDUG
I
1
2
4
1
2
4