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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
1 NEK1 related diseases
263520
Short rib-polydactyly syndorme, type II
Summary of query kinase
Query kinase
NEK1 (
Q96PY6
)
Kinase group
Other
Number of conformation types
0
Number of structural templates
49 (
Total 25 inhibitors
)
Number of NEK1 related diseases
1 (
263520
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
35
1AQ1A_STU
(CDK2)
Other
staurosporine
I
195
76
118
A
1AQ1A_STU
(CDK2)
Other
staurosporine
I
195
76
118
195
76
118
A
1QPJA_STU
(LCK)
Other
staurosporine
I
115
76
126
115
76
126
A
3HMOA_STU
(TTK)
Other
staurosporine
I
27
50
20
27
50
20
A
1NVQA_UCN
(CHEK1)
Other
UCN 02
I
179
65
79
179
65
79
A
1SM2A_STU
(ITK)
Other
staurosporine
I
99
104
128
99
104
128
A
1NVRA_STU
(CHEK1)
Other
staurosporine
I
179
71
79
179
71
79
A
1SNUA_STU
(ITK)
Other
staurosporine
I
99
104
128
99
104
128
A
1NXKA_STU
(MAPKAPK2)
Other
staurosporine
I
110
67
51
110
67
51
A
2HZ4A_4ST
(ABL1)
Other
staurosporine
I
159
103
156
159
103
156
A
1PKDA_UCN
(CDK2)
Other
UCN 02
I
195
67
118
195
67
118
A
1QPDA_STU
(LCK)
Other
staurosporine
I
115
76
126
115
76
126
A
2XK7A_30E
(NEK2)
Other
Erlotinib
I
2
26
1
2
26
1
A
2XK8A_5R1
(NEK2)
Other
4-[3-Amino-6...
I
4
34
5
4
34
5
A
2XKCA_4VQ
(NEK2)
Other
4-[3-Amino-6...
I
4
39
5
4
39
5
A
2XKDA_T3M
(NEK2)
Other
4-[3-Amino-6...
I
4
38
5
4
38
5
A
2XKEA_WI2
(NEK2)
Other
1-[3-Amino-6...
I
2
21
1
2
21
1
A
1ZZLA_TZY
(MAPK14)
Other
CP-808844
I
36
84
44
36
84
44
A
2XNPA_WCX
(NEK2)
Other
4-{5-[(1-Met...
I
12
34
17
12
34
17
A
3GFWA_S22
(TTK)
Other
1-(4-(4-(2-(...
I
21
4
18
21
4
18
A
3L8XA_N4D
(MAPK14)
Other
3cg2
I
91
104
65
91
104
65
A
2J90A_IZA
(DAPK3)
Other
Pyridone 6
I
40
50
42
40
50
42
A
3PJ3A_04L
(BTK)
Other
Imatinib
II
99
113
134
99
113
134
A
1OPLA_P16
(ABL1)
Other
PD166326
I
89
70
123
89
70
123
A
2IW6A_QQ2
(CDK2)
Other
2iw6
I
112
209
86
112
209
86
A
2I40A_BLZ
(CDK2)
Other
2i40
I
34
95
16
34
95
16
A
2FO0A_P16
(ABL1)
Other
PD166326
I
89
70
123
89
70
123
A
2J51A_DKI
(SLK)
Other
5-AMINO-3-{[...
I
90
11
103
90
11
103
A
2JFLA_DKI
(SLK)
Other
5-AMINO-3-{[...
I
90
11
103
90
11
103
A
2XNMA_WGZ
(NEK2)
Other
benzimidazol...
I
12
93
9
12
93
9
A
2G2HA_P16
(ABL1)
Other
PD166326
I
89
70
123
89
70
123
A
2XNNA_430
(NEK2)
Other
Kinome_3463
I
12
83
9
12
83
9
A
2HZIA_JIN
(ABL1)
Other
PD180970
I
90
77
120
90
77
120
A
1BL6A_SB6
(MAPK14)
Other
sb216995
I
46
110
50
46
110
50
A
2XNOA_ED8
(NEK2)
Other
5-{6-[(1-Met...
I
12
82
9
12
82
9
A
3PIYA_585
(BTK)
Other
R-406
I
93
17
123
93
17
123
B
14
1OKYA_STU
(PDPK1)
Other
staurosporine
I
179
67
109
B
1OKYA_STU
(PDPK1)
Other
staurosporine
I
179
67
109
179
67
109
B
3BKBA_STU
(FES)
Other
staurosporine
I
131
107
138
131
107
138
B
1OKZA_UCN
(PDPK1)
Other
UCN 02
I
179
60
109
179
60
109
B
3CBLA_STU
(FES)
Other
staurosporine
I
131
107
138
131
107
138
B
3CD3A_STU
(FES)
Other
staurosporine
I
131
107
138
131
107
138
B
3D7TA_STU
(CSK)
Other
staurosporine
I
70
68
99
70
68
99
B
2XKFA_BX1
(NEK2)
Other
1-[3-Amino-6...
I
4
30
8
4
30
8
B
2WQOA_VGK
(NEK2)
Other
4-[3-Amino-6...
I
8
51
12
8
51
12
B
2XK4A_OL2
(NEK2)
Other
4-[3-Amino-6...
I
8
44
12
8
44
12
B
2B7AA_IZA
(JAK2)
Other
Pyridone 6
I
34
12
65
34
12
65
B
3EFWA_AK8
(AURKA)
Other
3efw
I
100
59
105
100
59
105
B
1H07A_MFP
(CDK2)
Other
AC1NAKJQ
I
90
241
80
90
241
80
B
3MIYA_B49
(ITK)
Other
Sunitinib
I
70
74
110
70
74
110
B
3AMAA_SKE
(PRKACA)
Other
JNJ-7706621
I
46
26
35
46
26
35