Allelic Variants
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There are no related allelic variants
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| Number of involved diseases in the family |
90 |
| Number of LCK related diseases |
2 |
All kinase in this family
LCK
Allelic
Variants |
Disease Description |
Involved kinases
(This family) |
Inhibitor of
Involved Kinases |
Search
Disease |
| Prostate cancer | BRAF, CDK2, EGFR, FGFR1,
IGF1R, PDGFRA, PDGFRB | 75 | Link | | Leukemia | ABL1, BRAF, JAK2, KIT,
PDGFRB, TGFBR1 | 33 | Link | | Melanoma | BRAF, EGFR, FGFR1, IGF1R,
PDGFRA, PDGFRB | 39 | Link | | n/a | Epstein-Barr virus infection | CDC2, CDK2, EIF2AK2, LYN,
MAPK14 | 54 | Link | | n/a | Epithelial cell signaling in Helicobacter pylori infection | EGFR, LYN, MAPK14, SRC | 24 | Link | | n/a | Herpes simplex infection | CDC2, CDK2, EIF2AK2, JAK2 | 45 | Link | | n/a | Hepatitis C | BRAF, EGFR, EIF2AK2, MAPK14 | 14 | Link | | Lung cancer | ALK, BRAF, CDK2, EGFR | 49 | Link | | n/a | Shigellosis | ABL1, MAPK14, SRC | 25 | Link | | n/a | Thyroid cancer | BRAF, NTRK1, RET | 23 | Link | | n/a | Measles | CDK2, EIF2AK2, JAK2 | 43 | Link | | n/a | Glioma | EGFR, PDGFRA, PDGFRB | 22 | Link | | n/a | Influenza A | EIF2AK2, JAK2, MAPK14 | 9 | Link | | n/a | Tuberculosis | JAK2, MAPK14, SRC | 24 | Link | | n/a | Toxoplasmosis | JAK2, MAPK14 | 8 | Link | | n/a | Cervical cancer | EGFR, FGFR3 | 4 | Link | | Gastrointestinal stromal tumor | KIT, PDGFRA | 2 | Link | | n/a | Myeloproliferative disorder | JAK2, PDGFRB | 21 | Link | | n/a | Leishmaniasis | JAK2, MAPK14 | 8 | Link | | n/a | Choriocarcinoma | CSF1R, EGFR | 9 | Link | | Colorectal cancer | BRAF, FGFR3 | 6 | Link | | n/a | Chagas disease | MAPK14, TGFBR1 | 6 | Link | | Neuroblastoma | ALK, NTRK1 | 4 | Link | | Colon cancer | AURKA, SRC | 36 | Link | | n/a | Medullary thyroid carcinoma | NTRK1, RET | 18 | Link | | Adenocarcinoma of lung | BRAF, EGFR | 8 | Link | | n/a | Bladder cancer | EGFR, FGFR3 | 4 | Link | | Pfeiffer syndrome | FGFR1 | 21 | Link | | Kallmann syndrome | FGFR1 | 21 | Link | | n/a | Laryngeal cancer | EGFR | 3 | Link | | Jackson-Weiss syndrome | FGFR1 | 21 | Link | | Osteoglophonic dysplasia | FGFR1 | 21 | Link | | Trigonocephaly | FGFR1 | 21 | Link | | Hypogonadotropic hypogonadism | FGFR1 | 21 | Link | | n/a | Cocaine addiction | CDK5 | 1 | Link | | Gastric cancer | EGFR | 3 | Link | | n/a | Alcoholism | BRAF | 5 | Link | | n/a | Noonan syndrome and related disorders | BRAF | 5 | Link | | n/a | Malignant melanoma | BRAF | 5 | Link | | n/a | Pathogenic Escherichia coli infection | ABL1 | 5 | Link | | n/a | Viral myocarditis | ABL1 | 5 | Link | | Cardiofaciocutaneous syndrome | BRAF | 5 | Link | | LEOPARD syndrome | BRAF | 5 | Link | | n/a | Esophageal cancer | EGFR | 3 | Link | | n/a | Oral cancer | EGFR | 3 | Link | | n/a | Leukoencephalopathy, diffuse hereditary, with spheroids | CSF1R | 6 | Link | | Noonan syndrome | BRAF | 5 | Link | | n/a | Multiple myeloma | FGFR3 | 1 | Link | | Crouzon syndrome | FGFR3 | 1 | Link | | n/a | FGFR3-related short limb skeletal dysplasias | FGFR3 | 1 | Link | | n/a | Salmonella infection | MAPK14 | 5 | Link | | n/a | Pertussis | MAPK14 | 5 | Link | | n/a | Insensitivity to pain | NTRK1 | 2 | Link | | n/a | Amyotrophic lateral sclerosis | MAPK14 | 5 | Link | | SCID | LCK | 28 | Link | | Mast cell leukemia | KIT | 1 | Link | | Mastocytosis with associated hematologic disorder | KIT | 1 | Link | | n/a | Immunodeficiencies | LCK | 28 | Link | | n/a | Hypereosinophilic syndrome | PDGFRA | 1 | Link | | n/a | Renal agenesis and Renal adysplasia | RET | 16 | Link | | Loeys-Dietz syndrome | TGFBR1 | 1 | Link | | n/a | Familial thoracic aortic aneurysm and dissection | TGFBR1 | 1 | Link | | Multiple self-healing squamous epithelioma | TGFBR1 | 1 | Link | | Renal agenesis | RET | 16 | Link | | Pheochromocytoma | RET | 16 | Link | | Hirschsprung disease | RET | 16 | Link | | n/a | Congenital central hypoventilation syndrome | RET | 16 | Link | | Central hypoventilation syndrome | RET | 16 | Link | | Multiple endocrine neoplasia | RET | 16 | Link | | n/a | Germ cell tumors | KIT | 1 | Link | | Piebaldism | KIT | 1 | Link | | n/a | Nevus | FGFR3 | 1 | Link | | n/a | Spermatocytic seminoma | FGFR3 | 1 | Link | | n/a | Thanatophoric dysplasia | FGFR3 | 1 | Link | | n/a | Muenke syndrome | FGFR3 | 1 | Link | | LADD syndrome | FGFR3 | 1 | Link | | n/a | CATSHL syndrome | FGFR3 | 1 | Link | | n/a | Achondroplasia | FGFR3 | 1 | Link | | n/a | Hypochondroplasia | FGFR3 | 1 | Link | | n/a | Malignant pleural mesothelioma | IGF1R | 10 | Link | | n/a | Synovial sarcoma | IGF1R | 10 | Link | | n/a | Budd-Chiari syndrome | JAK2 | 3 | Link | | Myelofibrosis | JAK2 | 3 | Link | | Thrombocythemia | JAK2 | 3 | Link | | Polycythemia vera | JAK2 | 3 | Link | | Hyperinsulinemic hypoglycemia | INSR | 9 | Link | | Insulin-like growth factor I | IGF1R | 10 | Link | | n/a | Leprechaunism | INSR | 9 | Link | | Rabson-Mendenhall syndrome | INSR | 9 | Link | | Diabetes mellitus | INSR | 9 | Link |
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