Allelic Variants
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There are no related allelic variants
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Number of involved diseases in the family |
141 |
Number of NLK related diseases |
0 |
All kinase in this family
NLK
Allelic Variants |
Disease Description |
Involved kinases (This family) |
Inhibitor of Involved Kinases |
Search Disease |
n/a | Epstein-Barr virus infection | CDC2, CDK2, EIF2AK2, EIF2AK4, FGR, JAK1, JAK3, MAP2K3, MAP2K6, MAP3K14, MAPK12, MAPK13, MAPK14, SYK, TBK1 | 20 | Link | n/a | Influenza A | EIF2AK2, EIF2AK4, IRAK4, JAK1, JAK2, MAP2K1, MAP2K3, MAP2K6, MAPK1, MAPK12, MAPK13, MAPK14, PRKCA, RAF1, TBK1 | 61 | Link | n/a | Tuberculosis | CAMK2A, CAMK2B, IRAK4, JAK1, JAK2, MAPK1, MAPK12, MAPK13, MAPK14, PLK3, RAF1, SRC, SYK | 21 | Link | | Prostate cancer | CDK2, CHEK2, EGFR, EPHB2, FGFR1, FGFR2, IGF1R, INSRR, MAP2K1, MAPK1, PDPK1, RAF1 | 46 | Link | n/a | Measles | CDK2, CDK4, CDK6, EIF2AK2, EIF2AK4, FYN, IRAK4, JAK1, JAK2, JAK3, PRKCQ, TBK1 | 19 | Link | | Leukemia | ABL1, ABL2, CDK4, CDK6, JAK2, MAP2K1, MAPK1, PIM1, RAF1, RPS6KB1, RPS6KB2 | 15 | Link | n/a | Hepatitis C | EGFR, EIF2AK2, EIF2AK4, JAK1, MAPK1, MAPK12, MAPK13, MAPK14, RAF1, TBK1 | 42 | Link | n/a | Toxoplasmosis | IRAK4, JAK1, JAK2, MAP2K3, MAP2K6, MAPK1, MAPK12, MAPK13, MAPK14 | 13 | Link | | Melanoma | CDK4, CDK6, EGFR, FGFR1, IGF1R, MAP2K1, MAPK1, MET, RAF1 | 43 | Link | n/a | Epithelial cell signaling in Helicobacter pylori infection | CSK, EGFR, MAP3K14, MAPK12, MAPK13, MAPK14, MET, PAK1, SRC | 42 | Link | | Lung cancer | ALK, CDK2, CDK4, CDK6, EGFR, MAP3K8, PTK2, ROS1 | 43 | Link | n/a | Herpes simplex infection | CDC2, CDK2, EIF2AK2, EIF2AK4, JAK1, JAK2, TBK1 | 15 | Link | n/a | Alcoholism | CAMK4, CAMKK1, CAMKK2, MAP2K1, MAPK1, NTRK2, RAF1 | 12 | Link | n/a | Leishmaniasis | IRAK4, JAK1, JAK2, MAPK1, MAPK12, MAPK13, MAPK14 | 12 | Link | n/a | Shigellosis | ABL1, MAPK1, MAPK12, MAPK13, MAPK14, SRC | 20 | Link | n/a | Salmonella infection | MAPK1, MAPK12, MAPK13, MAPK14, PKN1, PKN2 | 13 | Link | n/a | Chagas disease | IRAK4, MAPK1, MAPK12, MAPK13, MAPK14 | 6 | Link | | Diabetes mellitus | INSR, MAPK1, PRKCD, PRKCE, PRKCZ | 15 | Link | n/a | Pertussis | IRAK4, MAPK1, MAPK12, MAPK13, MAPK14 | 6 | Link | n/a | Amyotrophic lateral sclerosis | MAP2K3, MAP2K6, MAPK12, MAPK13, MAPK14 | 11 | Link | | Neuroblastoma | ALK, NTRK1, NTRK2, NTRK3 | 16 | Link | n/a | Pathogenic Escherichia coli infection | ABL1, FYN, PRKCA | 61 | Link | n/a | Cervical cancer | CDK4, EGFR, FGFR3 | 40 | Link | n/a | Viral myocarditis | ABL1, ABL2, FYN | 13 | Link | n/a | Immunodeficiencies | JAK3, LCK, ZAP70 | 16 | Link | | Gastric cancer | EGFR, FGFR2, MET | 39 | Link | n/a | Prion diseases | FYN, MAP2K1, MAPK1 | 11 | Link | n/a | Bladder cancer | DAPK1, EGFR, FGFR3 | 39 | Link | | Jackson-Weiss syndrome | FGFR1, FGFR2 | 9 | Link | | SCID | JAK3, LCK | 16 | Link | | Pfeiffer syndrome | FGFR1, FGFR2 | 9 | Link | n/a | Thyroid cancer | NTRK1, RET | 18 | Link | n/a | Medullary thyroid carcinoma | NTRK1, RET | 18 | Link | | Mental retardation | CASK, PAK3 | 8 | Link | | Crouzon syndrome | FGFR2, FGFR3 | 8 | Link | | LADD syndrome | FGFR2, FGFR3 | 8 | Link | | Colon cancer | AURKA, SRC | 19 | Link | n/a | Amoebiasis | PRKCA, PTK2 | 57 | Link | n/a | Glioma | CDK4, EGFR | 40 | Link | n/a | Saethre-Chotzen syndrome | FGFR2 | 8 | Link | | Scaphocephaly | FGFR2 | 8 | Link | n/a | Scaphocephaly and Axenfeld-Rieger anomaly | FGFR2 | 8 | Link | | Osteoglophonic dysplasia | FGFR1 | 9 | Link | n/a | Multiple myeloma | FGFR3 | 7 | Link | n/a | Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis | FGFR2 | 8 | Link | | Beare-Stevenson cutis gyrata syndrome | FGFR2 | 8 | Link | | Kallmann syndrome | FGFR1 | 9 | Link | | Craniofacial-skeletal-dermatologic dysplasia | FGFR2 | 8 | Link | | Bent bone dysplasia syndrome | FGFR2 | 8 | Link | | Trigonocephaly | FGFR1 | 9 | Link | | Craniosynostosis | FGFR2 | 8 | Link | | Apert syndrome | FGFR2 | 8 | Link | | Osteosarcoma | CHEK2 | 5 | Link | | Hypogonadotropic hypogonadism | FGFR1 | 9 | Link | | Agammaglobulinemia | BTK | 5 | Link | n/a | Agammaglobulinemia and isolated hormone deficiency | BTK | 5 | Link | n/a | FG syndrome | CASK | 1 | Link | n/a | Malignant melanoma | CDK4 | 6 | Link | n/a | Pituitary Dwarfism | BTK | 5 | Link | n/a | Agammaglobulinemias | BTK | 5 | Link | | Fibrodysplasia ossificans progressiva | ACVR1 | 3 | Link | n/a | Maturity onset diabetes of the young | BLK | 8 | Link | n/a | Juvenile polyposis syndrome | BMPR1A | 2 | Link | n/a | Polyposis | BMPR1A | 2 | Link | n/a | Cocaine addiction | CDK5 | 5 | Link | n/a | Prader-Willi and Angelman syndromes | CDKL5 | 1 | Link | n/a | Esophageal cancer | EGFR | 38 | Link | n/a | Choriocarcinoma | EGFR | 38 | Link | n/a | Laryngeal cancer | EGFR | 38 | Link | | Adenocarcinoma of lung | EGFR | 38 | Link | n/a | Oral cancer | EGFR | 38 | Link | n/a | FGFR3-related short limb skeletal dysplasias | FGFR3 | 7 | Link | n/a | Early infantile epileptic encephalopathy | CDKL5 | 1 | Link | n/a | Angelman syndrome-like | CDKL5 | 1 | Link | n/a | Epileptic encephalopathy | CDKL5 | 1 | Link | | Breast cancer | CHEK2 | 5 | Link | | Li-Fraumeni syndrome | CHEK2 | 5 | Link | n/a | Spermatocytic seminoma | FGFR3 | 7 | Link | n/a | CATSHL syndrome | FGFR3 | 7 | Link | n/a | Glycogen storage diseases | PHKG2 | 9 | Link | n/a | Non-syndromic X-linked mental retardation | PAK3 | 8 | Link | n/a | Cirrhosis due to liver phosphorylase kinase deficiency | PHKG2 | 9 | Link | | Glycogen storage disease | PHKG2 | 9 | Link | n/a | African trypanosomiasis | PRKCA | 55 | Link | n/a | Vibrio cholerae infection | PRKCA | 55 | Link | n/a | Obesity | NTRK2 | 9 | Link | n/a | Insensitivity to pain | NTRK1 | 15 | Link | | Hepatocellular carcinoma | MET | 8 | Link | n/a | Autism suseptibility | MET | 8 | Link | n/a | Congenital myasthenic syndrome | MUSK | 5 | Link | n/a | Myasthenic syndrome | MUSK | 5 | Link | | Deafness | MYO3A | 2 | Link | n/a | Deafness, autosomal recessive | MYO3A | 2 | Link | n/a | Pituitary tumor | PRKCA | 55 | Link | n/a | Type I diabetes mellitus | PRKCQ | 8 | Link | n/a | Basal cell carcinoma | STK36 | 3 | Link | | Renal agenesis | RET | 11 | Link | n/a | Transient erythroblastopenia of childhood | TEC | 2 | Link | | Venous malformations | TEK | 32 | Link | | Selective T-cell defect | ZAP70 | 10 | Link | n/a | Rheumatoid arthritis | TEK | 32 | Link | | Pheochromocytoma | RET | 11 | Link | | Multiple endocrine neoplasia | RET | 11 | Link | | Noonan syndrome | RAF1 | 2 | Link | | LEOPARD syndrome | RAF1 | 2 | Link | n/a | Renal agenesis and Renal adysplasia | RET | 11 | Link | | Hirschsprung disease | RET | 11 | Link | | Central hypoventilation syndrome | RET | 11 | Link | n/a | Congenital central hypoventilation syndrome | RET | 11 | Link | n/a | Malaria | MET | 8 | Link | n/a | Cholangiocarcinoma | MET | 8 | Link | n/a | Endocrine-cerebroosteodysplasia | ICK | 2 | Link | n/a | Oguchi disease | GRK1 | 4 | Link | n/a | Malignant pleural mesothelioma | IGF1R | 5 | Link | n/a | Synovial sarcoma | IGF1R | 5 | Link | n/a | Leprechaunism | INSR | 5 | Link | | Insulin-like growth factor I | IGF1R | 5 | Link | n/a | Congenital stationary night blindness | GRK1 | 4 | Link | n/a | Cancer progression/metastasis | FGFR4 | 3 | Link | | Colorectal cancer | FGFR3 | 7 | Link | n/a | Achondroplasia | FGFR3 | 7 | Link | n/a | Hypochondroplasia | FGFR3 | 7 | Link | n/a | Muenke syndrome | FGFR3 | 7 | Link | n/a | Thanatophoric dysplasia | FGFR3 | 7 | Link | n/a | Nevus | FGFR3 | 7 | Link | | Rabson-Mendenhall syndrome | INSR | 5 | Link | | Hyperinsulinemic hypoglycemia | INSR | 5 | Link | n/a | Parkinson disease | LRRK2 | 5 | Link | n/a | Lewy body dementia | LRRK2 | 5 | Link | | REtinitis pigmentosa | MAK | 1 | Link | n/a | Noonan syndrome and related disorders | MAP2K1 | 4 | Link | | Renal cell carcinoma | MET | 8 | Link | | Cardiofaciocutaneous syndrome | MAP2K1 | 4 | Link | | Thrombocythemia | JAK2 | 10 | Link | n/a | Myeloproliferative disorder | JAK2 | 10 | Link | | IRAK4 deficiency | IRAK4 | 4 | Link | n/a | Invasive pneumococcal disease | IRAK4 | 4 | Link | | Lymphoproliferative syndrome | ITK | 6 | Link | | Polycythemia vera | JAK2 | 10 | Link | | Myelofibrosis | JAK2 | 10 | Link | n/a | Budd-Chiari syndrome | JAK2 | 10 | Link |
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