BioXGEM.
KIDFamMap
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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
4 JAK3 related diseases
H00091
T-B+Severe combined immunodeficiencies (SCIDs)
hsa05162
Measles
hsa05169
Epstein-Barr virus infection
600802
SCID, autosomal recessive, T-negative/B-positive type
Summary of query kinase
Query kinase
JAK3 (
P52333
)
Kinase group
TK
Number of conformation types
2
Number of structural templates
4 (
Total 450 inhibitors
)
Number of JAK3 related diseases
4 (
H00091
hsa05162
hsa05169
600802
)
Number of allelic variants
5 (
A58X
C565X
D169E
R445X
Y100C
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
3
1YVJA_4ST
(JAK3)
TK
staurosporine
I
96
90
126
A
1YVJA_4ST
(JAK3)
TK
staurosporine
I
96
90
126
96
90
126
A
3LXLA_IZA
(JAK3)
TK
Pyridone 6
I
30
11
63
30
11
63
A
3PJCA_PJC
(JAK3)
TK
3-(1h-Indol-...
I
8
11
25
8
11
25
B
1
3LXKA_MI1
(JAK3)
TK
CP690550
I
5
23
27
B
3LXKA_MI1
(JAK3)
TK
CP690550
I
5
23
27
5
23
27