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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
9 KIT related diseases
H00003
Acute myeloid leukemia (AML)
H00170
Piebaldism
hsa05221
Acute myeloid leukemia
606764
Gastrointestinal stromal tumor, somatic
273300
Germ cell tumors
601626
Leukemia, acute myeloid
OMIM
(164920)
Mast cell leukemia
OMIM
(164920)
Mastocytosis with associated hematologic disorder
OMIM
(164920)
Piebaldism
Summary of query kinase
Query kinase
KIT (
P10721
)
Kinase group
TK
Number of conformation types
2
Number of structural templates
4 (
Total 585 inhibitors
)
Number of KIT related diseases
9 (
H00003
H00170
hsa05221
606764
273300
601626
OMIM:164920
OMIM:164920
...
)
Number of allelic variants
15 (
D816H
D816V
D816Y
D820G
E583K
E839K
F584C
F584L
G664R
K642E
...
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
1
1PKGA_ADP
(KIT)
TK
Adenosine-5'...
I
10
10
42
A
1PKGA_ADP
(KIT)
TK
Adenosine-5'...
I
10
10
42
10
10
42
E
3
3G0EA_B49
(KIT)
TK
Sunitinib
I
37
40
78
E
3G0EA_B49
(KIT)
TK
Sunitinib
I
37
40
78
37
40
78
E
3G0FA_B49
(KIT)
TK
Sunitinib
I
37
40
78
37
40
78
E
1T46A_STI
(KIT)
TK
Imatinib
II
22
176
56
22
176
56