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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
18 AKT1 related diseases
H00539
PTEN hamartoma tumor syndrome (PHTS)
hsa05142
Chagas disease (American trypanosomiasis)
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05160
Hepatitis C
hsa05162
Measles
hsa05164
Influenza A
hsa05169
Epstein-Barr virus infection
hsa05215
Prostate cancer
hsa05218
Melanoma
hsa05220
Chronic myeloid leukemia
hsa05221
Acute myeloid leukemia
hsa05222
Small cell lung cancer
114480
Breast cancer, somatic
114500
Colorectal cancer, somatic
167000
Ovarian cancer, somatic
176920
Proteus syndrome, somatic
181500
{Schizophrenia, susceptibility to}
Summary of query kinase
Query kinase
AKT1 (
P31749
)
Kinase group
AGC
Number of conformation types
2
Number of structural templates
10 (
Total 955 inhibitors
)
Number of AKT1 related diseases
18 (
H00539
hsa05142
hsa05145
hsa05152
hsa05160
hsa05162
hsa05164
hsa05169
...
)
Number of allelic variants
1 (
E17K
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
B
9
3OCBA_XM1
(AKT1)
AGC
XM1
I
10
99
23
B
3OCBA_XM1
(AKT1)
AGC
XM1
I
10
99
23
10
99
23
B
3CQUA_CQU
(AKT1)
AGC
3cqu
I
7
15
27
7
15
27
B
3MVHA_WFE
(AKT1)
AGC
N-{[(3s)-3-A...
I
5
44
23
5
44
23
B
3MV5A_XFE
(AKT1)
AGC
(3r)-1-(5-Me...
I
3
14
26
3
14
26
B
3CQWA_CQW
(AKT1)
AGC
3cqw
I
3
8
23
3
8
23
B
3OW4A_SMY
(AKT1)
AGC
LY_317615
I
3
37
20
3
37
20
B
3QKKA_SMH
(AKT1)
AGC
CAS139298_40_1
I
2
23
17
2
23
17
B
3QKLA_SMR
(AKT1)
AGC
CAS139298_40_1
I
2
43
20
2
43
20
B
3QKMA_SM9
(AKT1)
AGC
CP_724714
I
1
31
17
1
31
17
F
1
3O96A_IQO
(AKT1)
AGC
1,3-Dihydro-...
III
1
98
17
F
3O96A_IQO
(AKT1)
AGC
1,3-Dihydro-...
III
1
98
17
1
98
17