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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
11 FGFR1 related diseases
H00255
Hypogonadotropic hypogonadism
H00443
Osteoglophonic dysplasia (OD)
H01207
Trigonocephaly
hsa05215
Prostate cancer
hsa05218
Melanoma
146110
Hypogonadotropic hypogonadism
123150
Jackson-Weiss syndrome
147950
Kallmann syndrome 2
166250
Osteoglophonic dysplasia
101600
Pfeiffer syndrome
190440
Trigonocephaly 1
Summary of query kinase
Query kinase
FGFR1 (
P11362
)
Kinase group
TK
Number of conformation types
2
Number of structural templates
8 (
Total 606 inhibitors
)
Number of FGFR1 related diseases
11 (
H00255
H00443
H01207
hsa05215
hsa05218
146110
123150
147950
...
)
Number of allelic variants
23 (
A167S
C379R
C381R
D768Y
G237S
G48S
I300T
L342S
N330I
N724K
...
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
7
1AGWA_SU2
(FGFR1)
TK
SU 4984
I
77
81
111
A
1AGWA_SU2
(FGFR1)
TK
SU 4984
I
77
81
111
77
81
111
A
3RHXA_3RH
(FGFR1)
TK
6-o-tolylqui...
I
27
31
67
27
31
67
A
1FGIA_SU1
(FGFR1)
TK
Indolin-2-on...
I
25
71
61
25
71
61
A
2FGIA_PD1
(FGFR1)
TK
Pyrido[2,3-d...
I
24
157
70
24
157
70
A
3C4FA_C4F
(FGFR1)
TK
AC1O6YNE
I
23
45
56
23
45
56
A
3GQLA_GQL
(FGFR1)
TK
HMS3401N17
I
14
14
58
14
14
58
A
3JS2A_VM1
(FGFR1)
TK
MolPort-008-...
I
1
1
8
1
1
8
B
1
3GQIA_ACP
(FGFR1)
TK
adenosine te...
I
13
6
56
B
3GQIA_ACP
(FGFR1)
TK
adenosine te...
I
13
6
56
13
6
56