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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
5 IGF1R related diseases
H00015
Malignant pleural mesothelioma
H00050
Synovial sarcoma
hsa05215
Prostate cancer
hsa05218
Melanoma
270450
Insulin-like growth factor I, resistance to
Summary of query kinase
Query kinase
IGF1R (
P08069
)
Kinase group
TK
Number of conformation types
2
Number of structural templates
14 (
Total 840 inhibitors
)
Number of IGF1R related diseases
5 (
H00015
H00050
hsa05215
hsa05218
270450
)
Number of allelic variants
5 (
K115N
R108Q
R481Q
R59X
R709Q
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
2
1K3AA_ACP
(IGF1R)
TK
adenosine te...
I
8
7
47
A
1K3AA_ACP
(IGF1R)
TK
adenosine te...
I
8
7
47
8
7
47
A
3D94A_D94
(IGF1R)
TK
3-[3-(4-Meth...
II
7
75
28
7
75
28
B
12
3F5PA_741
(IGF1R)
TK
3-cyanoquino...
I
60
123
81
B
3F5PA_741
(IGF1R)
TK
3-cyanoquino...
I
60
123
81
60
123
81
B
3LW0A_CCX
(IGF1R)
TK
5-vinyl-3-py...
III
53
30
101
53
30
101
B
1JQHA_ANP
(IGF1R)
TK
Phosphoamino...
I
21
12
61
21
12
61
B
3QQUA_01P
(IGF1R)
TK
N~2~-[3-Meth...
I
21
158
73
21
158
73
B
3LVPA_PDR
(IGF1R)
TK
DNC009399
I
18
59
52
18
59
52
B
2OJ9A_BMI
(IGF1R)
TK
BMI
I
10
75
37
10
75
37
B
3I81A_EBI
(IGF1R)
TK
BMS-754807
I
4
48
23
4
48
23
B
2ZM3A_575
(IGF1R)
TK
isoquinoline...
I
3
39
8
3
39
8
B
3NW6A_LGW
(IGF1R)
TK
AMG_706
I
3
27
19
3
27
19
B
3NW7A_LGV
(IGF1R)
TK
AMG_706
I
3
23
19
3
23
19
B
3NW5A_LGX
(IGF1R)
TK
AMG_706
I
3
27
19
3
27
19
B
3O23A_MQY
(IGF1R)
TK
(5s)-5-Methy...
II
2
8
9
2
8
9