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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
4 NTRK1 related diseases
H00032
Thyroid cancer
H00043
Neuroblastoma
256800
Insensitivity to pain, congenital, with anhidrosis
155240
Medullary thyroid carcinoma, familial
Summary of query kinase
Query kinase
NTRK1 (
P04629
)
Kinase group
TK
Number of conformation types
0
Number of structural templates
92 (
Total 199 inhibitors
)
Number of NTRK1 related diseases
4 (
H00032
H00043
256800
155240
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
51
1NVRA_STU
(CHEK1)
TK
staurosporine
I
179
71
79
A
1NVRA_STU
(CHEK1)
TK
staurosporine
I
179
71
79
179
71
79
A
1QPDA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
1QPJA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
1SM2A_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
1SNUA_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
1U59A_STU
(ZAP70)
TK
staurosporine
I
96
80
114
96
80
114
A
3CKXA_STU
(STK24)
TK
staurosporine
I
176
104
141
176
104
141
A
1BYGA_STU
(CSK)
TK
staurosporine
I
85
72
123
85
72
123
A
1XJDA_STU
(PRKCQ)
TK
staurosporine
I
121
101
106
121
101
106
A
1NVQA_UCN
(CHEK1)
TK
UCN 02
I
179
65
79
179
65
79
A
2HZ4A_4ST
(ABL1)
TK
staurosporine
I
159
103
156
159
103
156
A
3PA4A_C72
(CHEK1)
TK
2-(4-Chlorop...
I
10
79
24
10
79
24
A
2C0IA_L1G
(HCK)
TK
A-420983
I
61
269
86
61
269
86
A
2OFUA_1N9
(LCK)
TK
2-aminopyrim...
I
55
215
101
55
215
101
A
3MJ2A_MJG
(ITK)
TK
BMS-509744
I
6
54
19
6
54
19
A
3PA5A_C73
(CHEK1)
TK
2-(Carbamoyl...
I
15
74
20
15
74
20
A
3PA3A_C70
(CHEK1)
TK
2-(4-Chlorop...
I
11
72
16
11
72
16
A
2F4JA_VX6
(ABL1)
TK
VX-680
I
110
109
134
110
109
134
A
3E5AA_VX6
(AURKA)
TK
VX-680
I
57
107
93
57
107
93
A
1FGIA_SU1
(FGFR1)
TK
Indolin-2-on...
I
25
71
61
25
71
61
A
2X2KA_X2K
(RET)
TK
Semaxanib
I
23
30
58
23
30
58
A
2C0TA_L3G
(HCK)
TK
A-641359
I
48
260
84
48
260
84
A
2X2MA_X2M
(RET)
TK
Semaxanib
I
24
81
59
24
81
59
A
3BEAA_IXH
(CSF1R)
TK
Pyrido[2,3-d...
I
19
77
69
19
77
69
A
2H8HA_H8H
(SRC)
TK
Saracatinib
I
91
255
126
91
255
126
A
1ZYSA_199
(CHEK1)
TK
2,4-Diamino-...
I
31
92
52
31
92
52
A
3GQLA_GQL
(FGFR1)
TK
HMS3401N17
I
14
14
58
14
14
58
A
3BYOA_AM9
(LCK)
TK
AC1NS8OV
I
28
144
90
28
144
90
A
2IVUA_ZD6
(RET)
TK
Vandetanib
I
83
291
121
83
291
121
A
3LCDA_BDY
(CSF1R)
TK
Sunitinib
I
23
168
86
23
168
86
A
3AC3A_KSH
(LCK)
TK
imidazo[1,2-...
I
13
105
37
13
105
37
A
2JEDA_LG8
(PRKCQ)
TK
5-Arylidene-...
I
67
19
87
67
19
87
A
3IKAA_0UN
(EGFR)
TK
2jkk
I
76
120
108
76
120
108
A
1Y57A_MPZ
(SRC)
TK
MPZ
I
42
155
94
42
155
94
A
1NVSA_UCM
(CHEK1)
TK
SB218078
I
97
6
53
97
6
53
A
2J51A_DKI
(SLK)
TK
5-AMINO-3-{[...
I
90
11
103
90
11
103
A
3PIYA_585
(BTK)
TK
R-406
I
93
17
123
93
17
123
A
2JFLA_DKI
(SLK)
TK
5-AMINO-3-{[...
I
90
11
103
90
11
103
A
2ITTA_AEE
(EGFR)
TK
GNF-Pf-5343
I
26
170
77
26
170
77
A
2Z7SA_P01
(RPS6KA1)
TK
Lopac0_000938
I
32
214
49
32
214
49
A
3F9NA_38M
(CHEK1)
TK
Sunitinib
I
3
9
16
3
9
16
A
2XBAA_571
(ALK)
TK
5-Amido-pyrr...
I
17
55
50
17
55
50
A
3BPRA_OLP
(MERTK)
TK
compound 52
I
9
10
19
9
10
19
A
2RFNA_AM7
(MET)
TK
pyrimidone, 22
I
10
41
22
10
41
22
A
2JIUA_AEE
(EGFR)
TK
GNF-Pf-5343
I
26
170
77
26
170
77
A
3OCSA_746
(BTK)
TK
CGI1746, 2
I
25
89
76
25
89
76
A
2ZYBA_KSL
(LCK)
TK
DB08056
I
36
172
80
36
172
80
A
3EFKA_MT4
(MET)
TK
pyrimidone, 50
I
9
51
22
9
51
22
A
3NLBA_5BE
(CHEK1)
TK
38P
I
45
115
49
45
115
49
A
1AGWA_SU2
(FGFR1)
TK
SU 4984
I
77
81
111
77
81
111
A
3PJ3A_04L
(BTK)
TK
Imatinib
II
99
113
134
99
113
134
B
35
2XA4A_AZ5
(JAK2)
TK
AZD1480, AZ...
I
15
85
58
B
2XA4A_AZ5
(JAK2)
TK
AZD1480, AZ...
I
15
85
58
15
85
58
B
3LCSA_STU
(ALK)
TK
staurosporine
I
73
100
109
73
100
109
B
2ITQA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
2ITUA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
2ITWA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3BKBA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CBLA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CD3A_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3D7TA_STU
(CSK)
TK
staurosporine
I
70
68
99
70
68
99
B
3MIYA_B49
(ITK)
TK
Sunitinib
I
70
74
110
70
74
110
B
3IOKA_1P6
(JAK2)
TK
PTK_787
I
16
98
47
16
98
47
B
3AOXA_EMH
(ALK)
TK
BIRB_796
I
34
28
85
34
28
85
B
3EFWA_AK8
(AURKA)
TK
3efw
I
100
59
105
100
59
105
B
3CJFA_SAV
(KDR)
TK
GW_2580
I
11
50
35
11
50
35
B
2XRUA_400
(AURKA)
TK
VX_680
I
33
152
63
33
152
63
B
3I81A_EBI
(IGF1R)
TK
BMS-754807
I
4
48
23
4
48
23
B
2BMCA_MPY
(AURKA)
TK
PHA-680632
I
107
108
107
107
108
107
B
2ITOA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
2ITYA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
2ITZA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
3LW0A_CCX
(IGF1R)
TK
5-vinyl-3-py...
III
53
30
101
53
30
101
B
2VWUA_7X1
(EPHB4)
TK
Chlorobenzod...
I
77
287
111
77
287
111
B
3F5PA_741
(IGF1R)
TK
3-cyanoquino...
I
60
123
81
60
123
81
B
3P9JA_P9J
(AURKA)
TK
4-[(5-Methyl...
I
32
50
54
32
50
54
B
3COHA_83H
(AURKA)
TK
AKI-001
I
79
88
65
79
88
65
B
2XB7A_GUI
(ALK)
TK
NVP-TAE684
I
71
66
107
71
66
107
B
2ITPA_AEE
(EGFR)
TK
GNF-Pf-5343
I
24
168
73
24
168
73
B
3H0YA_48B
(AURKA)
TK
2,4-Bisanili...
I
7
24
26
7
24
26
B
1YOMA_P01
(SRC)
TK
Lopac0_000938
I
27
95
57
27
95
57
B
2B7AA_IZA
(JAK2)
TK
Pyridone 6
I
34
12
65
34
12
65
B
3EKNA_GS3
(INSR)
TK
pyrrolo[2,3-...
I
90
215
127
90
215
127
B
3NZ0A_IZA
(TYK2)
TK
Pyridone 6
I
12
3
24
12
3
24
B
2J6MA_AEE
(EGFR)
TK
GNF-Pf-5343
I
24
168
73
24
168
73
B
3IO7A_1P5
(JAK2)
TK
CP_690550
I
24
65
60
24
65
60
B
3NRMA_NRM
(AURKA)
TK
CAS404828_08_6
I
32
33
60
32
33
60
E
6
3CTJA_320
(MET)
TK
3ctj
II
3
98
13
E
3CTJA_320
(MET)
TK
3ctj
II
3
98
13
3
98
13
E
3LQ8A_88Z
(MET)
TK
AZD_1152HQPA
II
19
71
36
19
71
36
E
3C1XA_CKK
(MET)
TK
AZD_1152HQPA
II
19
77
36
19
77
36
E
3CE3A_1FN
(MET)
TK
3ce3
II
4
81
13
4
81
13
E
3L8VA_L8V
(MET)
TK
L8V
II
3
47
13
3
47
13
E
3CTHA_319
(MET)
TK
3cth
II
3
58
13
3
58
13