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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
Summary of query kinase
Query kinase
YES1 (
P07947
)
Kinase group
TK
Number of conformation types
0
Number of structural templates
145 (
Total 149 inhibitors
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
94
2IVUA_ZD6
(RET)
TK
Vandetanib
I
83
291
121
A
2IVUA_ZD6
(RET)
TK
Vandetanib
I
83
291
121
83
291
121
A
2DQ7X_STU
(FYN)
TK
staurosporine
I
91
74
124
91
74
124
A
1QPDA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
2HZ4A_4ST
(ABL1)
TK
staurosporine
I
159
103
156
159
103
156
A
3CKXA_STU
(STK24)
TK
staurosporine
I
176
104
141
176
104
141
A
1QPJA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
1SM2A_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
1SNUA_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
1U59A_STU
(ZAP70)
TK
staurosporine
I
96
80
114
96
80
114
A
1XBCA_STU
(SYK)
TK
staurosporine
I
71
72
105
71
72
105
A
3A4OX_STU
(LYN)
TK
staurosporine
I
73
70
88
73
70
88
A
1AQ1A_STU
(CDK2)
TK
staurosporine
I
195
76
118
195
76
118
A
1XJDA_STU
(PRKCQ)
TK
staurosporine
I
121
101
106
121
101
106
A
1BYGA_STU
(CSK)
TK
staurosporine
I
85
72
123
85
72
123
A
1YVJA_4ST
(JAK3)
TK
staurosporine
I
96
90
126
96
90
126
A
1PKDA_UCN
(CDK2)
TK
UCN 02
I
195
67
118
195
67
118
A
2JAMA_J60
(CAMK1G)
TK
SU11652
I
50
65
32
50
65
32
A
2H8HA_H8H
(SRC)
TK
Saracatinib
I
91
255
126
91
255
126
A
3OCTA_1N1
(BTK)
TK
Dasatinib
I
56
32
103
56
32
103
A
2VTTA_LZD
(CDK2)
TK
pyrazole dia...
I
158
42
111
158
42
111
A
2IW6A_QQ2
(CDK2)
TK
2iw6
I
112
209
86
112
209
86
A
2GQGA_1N1
(ABL1)
TK
Dasatinib
I
74
32
117
74
32
117
A
3K54A_1N1
(BTK)
TK
Dasatinib
I
56
32
103
56
32
103
A
2F4JA_VX6
(ABL1)
TK
VX-680
I
110
109
134
110
109
134
A
2WIHA_P48
(CDK2)
TK
VX_680
I
111
425
105
111
425
105
A
2XYNA_VX6
(ABL2)
TK
VX-680
I
79
101
105
79
101
105
A
2Z7SA_P01
(RPS6KA1)
TK
Lopac0_000938
I
32
214
49
32
214
49
A
3DOGA_NNN
(CDK2)
TK
NSC743927
I
50
239
48
50
239
48
A
1R78A_FMD
(CDK2)
TK
4-alkynyl ox...
I
127
24
97
127
24
97
A
1M17A_AQ4
(EGFR)
TK
Erlotinib
I
43
166
82
43
166
82
A
1OI9A_N20
(CDK2)
TK
NU-6086
I
52
80
61
52
80
61
A
2C0IA_L1G
(HCK)
TK
A-420983
I
61
269
86
61
269
86
A
3FC1X_52P
(MAPK14)
TK
VX-745
I
12
6
21
12
6
21
A
2C0TA_L3G
(HCK)
TK
A-641359
I
48
260
84
48
260
84
A
3HP5A_52P
(MAPK14)
TK
VX-745
I
12
6
21
12
6
21
A
2OFUA_1N9
(LCK)
TK
2-aminopyrim...
I
55
215
101
55
215
101
A
3EOCA_T2A
(CDK2)
TK
5-methyl-7-p...
I
42
148
62
42
148
62
A
3PJ2A_04K
(BTK)
TK
PD166285
I
19
51
70
19
51
70
A
3FSFA_FSS
(MAPK14)
TK
AST_487
I
9
52
40
9
52
40
A
3L8XA_N4D
(MAPK14)
TK
3cg2
I
91
104
65
91
104
65
A
3EIDA_PO5
(CDK2)
TK
AC1O6YZF
I
63
211
77
63
211
77
A
3KMMA_LHL
(LCK)
TK
AZD_1152HQPA
I
29
99
95
29
99
95
A
3BYMA_AM0
(LCK)
TK
triazine 34
I
39
145
100
39
145
100
A
3PJ1A_LHL
(BTK)
TK
AZD_1152HQPA
I
30
99
96
30
99
96
A
3GENA_B43
(BTK)
TK
7-Cyclopenty...
I
29
110
67
29
110
67
A
3EZRA_EZR
(CDK2)
TK
indazole-ben...
I
30
145
62
30
145
62
A
3EZVA_EZV
(CDK2)
TK
EZV
I
36
194
65
36
194
65
A
2JEDA_LG8
(PRKCQ)
TK
5-Arylidene-...
I
67
19
87
67
19
87
A
1G5SA_I17
(CDK2)
TK
H724
I
43
170
58
43
170
58
A
3RI1A_3RH
(FGFR2)
TK
6-o-tolylqui...
I
29
33
72
29
33
72
A
2ZB1A_GK4
(MAPK14)
TK
biphenyl ami...
II
55
57
54
55
57
54
A
2HZIA_JIN
(ABL1)
TK
PD180970
I
90
77
120
90
77
120
A
3F5XA_EZV
(CDK2)
TK
EZV
I
36
194
65
36
194
65
A
1OUKA_084
(MAPK14)
TK
1ouk
I
24
139
46
24
139
46
A
3DDPA_RC8
(CDK2)
TK
Roscovitine
I
42
133
57
42
133
57
A
2R3NA_SCZ
(CDK2)
TK
AC1LZZHM
I
46
175
57
46
175
57
A
2IW8A_4SP
(CDK2)
TK
nu6102
I
30
33
30
30
33
30
A
3E92A_G6A
(MAPK14)
TK
3e92
I
56
59
55
56
59
55
A
3C4CA_324
(BRAF)
TK
PLX4720
I
35
5
58
35
5
58
A
3LQ5A_SLQ
(CDK9)
TK
Roscovitine
I
25
130
37
25
130
37
A
2ZYBA_KSL
(LCK)
TK
DB08056
I
36
172
80
36
172
80
A
2IW9A_4SP
(CDK2)
TK
nu6102
I
30
33
30
30
33
30
A
3IPHA_G11
(MAPK14)
TK
HMS3303K05
I
57
108
55
57
108
55
A
3C4DA_325
(BRAF)
TK
PLX4720
I
35
5
58
35
5
58
A
1YOLA_S03
(SRC)
TK
QGPSFIYTQAON...
I
30
114
75
30
114
75
A
1XBBA_STI
(SYK)
TK
Imatinib
I
31
170
75
31
170
75
A
1QCFA_PP1
(HCK)
TK
PP1
I
31
65
68
31
65
68
A
3EJ1A_5BP
(CDK2)
TK
AC1OCFRV
I
46
92
62
46
92
62
A
3ACJA_KSS
(LCK)
TK
6,7-dimethox...
I
13
7
25
13
7
25
A
3OG7A_032
(BRAF)
TK
PLX4720
I
35
5
58
35
5
58
A
1Y57A_MPZ
(SRC)
TK
MPZ
I
42
155
94
42
155
94
A
2ZM4A_KSM
(LCK)
TK
BMS-279700
I
25
179
75
25
179
75
A
1QPEA_PP2
(LCK)
TK
AG 1879
I
29
63
51
29
63
51
A
1H1SA_4SP
(CDK2)
TK
nu6102
I
30
33
30
30
33
30
A
3ACKA_KSR
(LCK)
TK
AC1O6YMO
I
23
42
56
23
42
56
A
3PJ3A_04L
(BTK)
TK
Imatinib
II
99
113
134
99
113
134
A
3FQSA_585
(SYK)
TK
R-406
I
64
28
102
64
28
102
A
1WZYA_F29
(MAPK1)
TK
AC1O4W7N
I
27
48
33
27
48
33
A
1OGUA_ST8
(CDK2)
TK
ST8
I
31
21
34
31
21
34
A
3C4FA_C4F
(FGFR1)
TK
AC1O6YNE
I
23
45
56
23
45
56
A
1OPLA_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
3IKAA_0UN
(EGFR)
TK
2jkk
I
76
120
108
76
120
108
A
2IVVA_PP1
(RET)
TK
PP1
I
27
46
63
27
46
63
A
1OIYA_N41
(CDK2)
TK
N41
I
33
49
34
33
49
34
A
2BHEA_BRY
(CDK2)
TK
BRY
I
51
31
35
51
31
35
A
2FO0A_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
3PIYA_585
(BTK)
TK
R-406
I
93
17
123
93
17
123
A
3EQRA_T74
(TNK2)
TK
T74
I
34
181
86
34
181
86
A
3HA8A_5JZ
(MAPK14)
TK
DEL-B, 14b
I
59
89
62
59
89
62
A
3B2WA_9NH
(LCK)
TK
MLS000911569
II
30
32
98
30
32
98
A
1AGWA_SU2
(FGFR1)
TK
SU 4984
I
77
81
111
77
81
111
A
1BL7A_SB4
(MAPK14)
TK
SB220025
I
22
159
29
22
159
29
A
3RHXA_3RH
(FGFR1)
TK
6-o-tolylqui...
I
27
31
67
27
31
67
A
2G2HA_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
B
41
3CD3A_STU
(FES)
TK
staurosporine
I
131
107
138
B
3CD3A_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
2ITOA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
2ITQA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3D7TA_STU
(CSK)
TK
staurosporine
I
70
68
99
70
68
99
B
2ITYA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
2ITUA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3LCSA_STU
(ALK)
TK
staurosporine
I
73
100
109
73
100
109
B
2ITZA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
2ITWA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3BKBA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CBLA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3MIYA_B49
(ITK)
TK
Sunitinib
I
70
74
110
70
74
110
B
2VWUA_7X1
(EPHB4)
TK
Chlorobenzod...
I
77
287
111
77
287
111
B
1H00A_FAP
(CDK2)
TK
AC1NAE4F
I
50
94
75
50
94
75
B
1H07A_MFP
(CDK2)
TK
AC1NAKJQ
I
90
241
80
90
241
80
B
1DI8A_DTQ
(CDK2)
TK
whi-p180
I
26
68
46
26
68
46
B
1UNLA_RRC
(CDK5)
TK
roscovitine
I
45
237
47
45
237
47
B
1YOMA_P01
(SRC)
TK
Lopac0_000938
I
27
95
57
27
95
57
B
2A4LA_RRC
(CDK2)
TK
roscovitine
I
50
240
50
50
240
50
B
3DDQA_RRC
(CDK2)
TK
roscovitine
I
50
240
50
50
240
50
B
3PJ8A_404
(CDK2)
TK
imidazo[2,1-...
I
47
223
49
47
223
49
B
3NS9A_NS9
(CDK2)
TK
pyrazolo[1,5...
I
44
196
47
44
196
47
B
1CKPA_PVB
(CDK2)
TK
Purvalanol B
I
35
76
36
35
76
36
B
2X9FA_X9F
(EPHB4)
TK
X9F
I
46
19
86
46
19
86
B
1W0XC_OLO
(CDK2)
TK
olomoucine
I
43
195
47
43
195
47
B
3AOXA_EMH
(ALK)
TK
BIRB_796
I
34
28
85
34
28
85
B
3F5PA_741
(IGF1R)
TK
3-cyanoquino...
I
60
123
81
60
123
81
B
2A0CX_CK9
(CDK2)
TK
purine deriv...
I
45
226
50
45
226
50
B
1OIRA_HDY
(CDK2)
TK
AC1O6YZF
I
51
203
64
51
203
64
B
2C6OA_4SP
(CDK2)
TK
nu6102
I
23
33
27
23
33
27
B
3EKNA_GS3
(INSR)
TK
pyrrolo[2,3-...
I
90
215
127
90
215
127
B
3QQUA_01P
(IGF1R)
TK
N~2~-[3-Meth...
I
21
158
73
21
158
73
B
3LVPA_PDR
(IGF1R)
TK
DNC009399
I
18
59
52
18
59
52
B
1V1KA_3FP
(CDK2)
TK
AC1NBL9K
I
11
92
39
11
92
39
B
2R3JA_SCJ
(CDK2)
TK
2r3j
I
27
99
49
27
99
49
B
3LW0A_CCX
(IGF1R)
TK
5-vinyl-3-py...
III
53
30
101
53
30
101
B
2VX1A_7X8
(EPHB4)
TK
DB07256
I
19
37
15
19
37
15
B
2R3KA_SCQ
(CDK2)
TK
2r3j
I
28
95
49
28
95
49
B
2C6IA_DT1
(CDK2)
TK
2c6i
I
27
41
48
27
41
48
B
3MTLA_FEF
(PCTK1)
TK
indirubin de...
I
16
3
23
16
3
23
B
2XB7A_GUI
(ALK)
TK
NVP-TAE684
I
71
66
107
71
66
107
D
1
3AQVA_TAK
(PRKAA2)
TK
dorsomorphin
I
12
41
19
D
3AQVA_TAK
(PRKAA2)
TK
dorsomorphin
I
12
41
19
12
41
19
E
8
3G0EA_B49
(KIT)
TK
Sunitinib
I
37
40
78
E
3G0EA_B49
(KIT)
TK
Sunitinib
I
37
40
78
37
40
78
E
3G0FA_B49
(KIT)
TK
Sunitinib
I
37
40
78
37
40
78
E
2BAKA_AQZ
(MAPK14)
TK
2bak
II
8
153
20
8
153
20
E
1KV2A_B96
(MAPK14)
TK
Doramapimod
II
8
92
20
8
92
20
E
2OG8A_1N8
(LCK)
TK
1N8
II
35
190
69
35
190
69
E
3HV6A_R39
(MAPK14)
TK
R39
II
8
74
20
8
74
20
E
1T46A_STI
(KIT)
TK
Imatinib
II
22
176
56
22
176
56
E
3HECA_STI
(MAPK14)
TK
Imatinib
II
7
158
20
7
158
20
F
1
2PL0A_STI
(LCK)
TK
Imatinib
II
12
142
33
F
2PL0A_STI
(LCK)
TK
Imatinib
II
12
142
33
12
142
33