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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
1 NTRK3 related diseases
H00043
Neuroblastoma
Summary of query kinase
Query kinase
NTRK3 (
Q16288
)
Kinase group
TK
Number of conformation types
0
Number of structural templates
131 (
Total 102 inhibitors
)
Number of NTRK3 related diseases
1 (
H00043
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
67
1XBCA_STU
(SYK)
TK
staurosporine
I
71
72
105
A
1XBCA_STU
(SYK)
TK
staurosporine
I
71
72
105
71
72
105
A
1NVRA_STU
(CHEK1)
TK
staurosporine
I
179
71
79
179
71
79
A
1XJDA_STU
(PRKCQ)
TK
staurosporine
I
121
101
106
121
101
106
A
1YVJA_4ST
(JAK3)
TK
staurosporine
I
96
90
126
96
90
126
A
1QPDA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
2DQ7X_STU
(FYN)
TK
staurosporine
I
91
74
124
91
74
124
A
3CKXA_STU
(STK24)
TK
staurosporine
I
176
104
141
176
104
141
A
1QPJA_STU
(LCK)
TK
staurosporine
I
115
76
126
115
76
126
A
2HZ4A_4ST
(ABL1)
TK
staurosporine
I
159
103
156
159
103
156
A
1SM2A_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
1SNUA_STU
(ITK)
TK
staurosporine
I
99
104
128
99
104
128
A
1AQ1A_STU
(CDK2)
TK
staurosporine
I
195
76
118
195
76
118
A
1U59A_STU
(ZAP70)
TK
staurosporine
I
96
80
114
96
80
114
A
1NVQA_UCN
(CHEK1)
TK
UCN 02
I
179
65
79
179
65
79
A
1PKDA_UCN
(CDK2)
TK
UCN 02
I
195
67
118
195
67
118
A
2C0IA_L1G
(HCK)
TK
A-420983
I
61
269
86
61
269
86
A
2OFUA_1N9
(LCK)
TK
2-aminopyrim...
I
55
215
101
55
215
101
A
2VTTA_LZD
(CDK2)
TK
pyrazole dia...
I
158
42
111
158
42
111
A
2Z7SA_P01
(RPS6KA1)
TK
Lopac0_000938
I
32
214
49
32
214
49
A
2F4JA_VX6
(ABL1)
TK
VX-680
I
110
109
134
110
109
134
A
3BPRA_OLP
(MERTK)
TK
compound 52
I
9
10
19
9
10
19
A
2WIHA_P48
(CDK2)
TK
VX_680
I
111
425
105
111
425
105
A
3E5AA_VX6
(AURKA)
TK
VX-680
I
57
107
93
57
107
93
A
1R78A_FMD
(CDK2)
TK
4-alkynyl ox...
I
127
24
97
127
24
97
A
2X2MA_X2M
(RET)
TK
Semaxanib
I
24
81
59
24
81
59
A
2C0TA_L3G
(HCK)
TK
A-641359
I
48
260
84
48
260
84
A
3DOGA_NNN
(CDK2)
TK
NSC743927
I
50
239
48
50
239
48
A
2BRNA_DF1
(CHEK1)
TK
pyrrolopyrim...
I
30
119
42
30
119
42
A
2BROA_DF2
(CHEK1)
TK
pyrrolopyrim...
I
29
109
40
29
109
40
A
2H8HA_H8H
(SRC)
TK
Saracatinib
I
91
255
126
91
255
126
A
2JEDA_LG8
(PRKCQ)
TK
5-Arylidene-...
I
67
19
87
67
19
87
A
2IW6A_QQ2
(CDK2)
TK
2iw6
I
112
209
86
112
209
86
A
2J51A_DKI
(SLK)
TK
5-AMINO-3-{[...
I
90
11
103
90
11
103
A
2BHEA_BRY
(CDK2)
TK
BRY
I
51
31
35
51
31
35
A
2JFLA_DKI
(SLK)
TK
5-AMINO-3-{[...
I
90
11
103
90
11
103
A
1FGIA_SU1
(FGFR1)
TK
Indolin-2-on...
I
25
71
61
25
71
61
A
1G5SA_I17
(CDK2)
TK
H724
I
43
170
58
43
170
58
A
2R3NA_SCZ
(CDK2)
TK
AC1LZZHM
I
46
175
57
46
175
57
A
1OGUA_ST8
(CDK2)
TK
ST8
I
31
21
34
31
21
34
A
3LXLA_IZA
(JAK3)
TK
Pyridone 6
I
30
11
63
30
11
63
A
2HOGA_710
(CHEK1)
TK
3-(Indol-2-y...
I
33
66
51
33
66
51
A
3IKAA_0UN
(EGFR)
TK
2jkk
I
76
120
108
76
120
108
A
1AGWA_SU2
(FGFR1)
TK
SU 4984
I
77
81
111
77
81
111
A
2ZYBA_KSL
(LCK)
TK
DB08056
I
36
172
80
36
172
80
A
1OIYA_N41
(CDK2)
TK
N41
I
33
49
34
33
49
34
A
3LXPA_IZA
(TYK2)
TK
Pyridone 6
I
9
3
20
9
3
20
A
3EIDA_PO5
(CDK2)
TK
AC1O6YZF
I
63
211
77
63
211
77
A
3PIYA_585
(BTK)
TK
R-406
I
93
17
123
93
17
123
A
3EJ1A_5BP
(CDK2)
TK
AC1OCFRV
I
46
92
62
46
92
62
A
2IVUA_ZD6
(RET)
TK
Vandetanib
I
83
291
121
83
291
121
A
2ZM4A_KSM
(LCK)
TK
BMS-279700
I
25
179
75
25
179
75
A
3PA5A_C73
(CHEK1)
TK
2-(Carbamoyl...
I
15
74
20
15
74
20
A
1OPLA_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
2IW8A_4SP
(CDK2)
TK
nu6102
I
30
33
30
30
33
30
A
2FO0A_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
1NVSA_UCM
(CHEK1)
TK
SB218078
I
97
6
53
97
6
53
A
3OT3A_22K
(CHEK1)
TK
INCB18424
I
13
30
13
13
30
13
A
2IW9A_4SP
(CDK2)
TK
nu6102
I
30
33
30
30
33
30
A
2G2HA_P16
(ABL1)
TK
PD166326
I
89
70
123
89
70
123
A
3DDPA_RC8
(CDK2)
TK
Roscovitine
I
42
133
57
42
133
57
A
3PJ3A_04L
(BTK)
TK
Imatinib
II
99
113
134
99
113
134
A
2HZIA_JIN
(ABL1)
TK
PD180970
I
90
77
120
90
77
120
A
2X2KA_X2K
(RET)
TK
Semaxanib
I
23
30
58
23
30
58
A
2BRMA_DFZ
(CHEK1)
TK
DFZ
I
21
88
36
21
88
36
A
2C3KA_ABO
(CHEK1)
TK
ABO
I
15
47
31
15
47
31
A
1H1SA_4SP
(CDK2)
TK
nu6102
I
30
33
30
30
33
30
A
3FQSA_585
(SYK)
TK
R-406
I
64
28
102
64
28
102
B
41
3BKBA_STU
(FES)
TK
staurosporine
I
131
107
138
B
3BKBA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CBLA_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3CD3A_STU
(FES)
TK
staurosporine
I
131
107
138
131
107
138
B
3MIYA_B49
(ITK)
TK
Sunitinib
I
70
74
110
70
74
110
B
3D7TA_STU
(CSK)
TK
staurosporine
I
70
68
99
70
68
99
B
2ITQA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
3LCSA_STU
(ALK)
TK
staurosporine
I
73
100
109
73
100
109
B
2ITUA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
2ITWA_STU
(EGFR)
TK
staurosporine
I
80
85
106
80
85
106
B
2WKMA_PFY
(MET)
TK
PHA-665752
I
38
34
98
38
34
98
B
1YOMA_P01
(SRC)
TK
Lopac0_000938
I
27
95
57
27
95
57
B
3CJFA_SAV
(KDR)
TK
GW_2580
I
11
50
35
11
50
35
B
3DDQA_RRC
(CDK2)
TK
roscovitine
I
50
240
50
50
240
50
B
3AOXA_EMH
(ALK)
TK
BIRB_796
I
34
28
85
34
28
85
B
1CKPA_PVB
(CDK2)
TK
Purvalanol B
I
35
76
36
35
76
36
B
1W0XC_OLO
(CDK2)
TK
olomoucine
I
43
195
47
43
195
47
B
3NS9A_NS9
(CDK2)
TK
pyrazolo[1,5...
I
44
196
47
44
196
47
B
2A0CX_CK9
(CDK2)
TK
purine deriv...
I
45
226
50
45
226
50
B
3PJ8A_404
(CDK2)
TK
imidazo[2,1-...
I
47
223
49
47
223
49
B
2A4LA_RRC
(CDK2)
TK
roscovitine
I
50
240
50
50
240
50
B
3EFWA_AK8
(AURKA)
TK
3efw
I
100
59
105
100
59
105
B
1H07A_MFP
(CDK2)
TK
AC1NAKJQ
I
90
241
80
90
241
80
B
3PY0A_SU9
(CDK2)
TK
SU 9516
I
25
19
33
25
19
33
B
3PY1A_SU9
(CDK2)
TK
SU 9516
I
25
19
33
25
19
33
B
2ITOA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
2ITYA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
2ITZA_IRE
(EGFR)
TK
Gefitinib
I
69
313
99
69
313
99
B
1PF8A_SU9
(CDK2)
TK
SU 9516
I
25
19
33
25
19
33
B
2VWUA_7X1
(EPHB4)
TK
Chlorobenzod...
I
77
287
111
77
287
111
B
3F5PA_741
(IGF1R)
TK
3-cyanoquino...
I
60
123
81
60
123
81
B
2BMCA_MPY
(AURKA)
TK
PHA-680632
I
107
108
107
107
108
107
B
2C6IA_DT1
(CDK2)
TK
2c6i
I
27
41
48
27
41
48
B
3NZ0A_IZA
(TYK2)
TK
Pyridone 6
I
12
3
24
12
3
24
B
3NRMA_NRM
(AURKA)
TK
CAS404828_08_6
I
32
33
60
32
33
60
B
2C6OA_4SP
(CDK2)
TK
nu6102
I
23
33
27
23
33
27
B
3P9JA_P9J
(AURKA)
TK
4-[(5-Methyl...
I
32
50
54
32
50
54
B
3LW0A_CCX
(IGF1R)
TK
5-vinyl-3-py...
III
53
30
101
53
30
101
B
3COHA_83H
(AURKA)
TK
AKI-001
I
79
88
65
79
88
65
B
2B7AA_IZA
(JAK2)
TK
Pyridone 6
I
34
12
65
34
12
65
B
3EYHA_IZA
(JAK1)
TK
Pyridone 6
I
21
19
54
21
19
54
B
1OIRA_HDY
(CDK2)
TK
AC1O6YZF
I
51
203
64
51
203
64
D
4
1R0PA_KSA
(MET)
TK
k-252a
I
28
79
64
D
1R0PA_KSA
(MET)
TK
k-252a
I
28
79
64
28
79
64
D
3AQVA_TAK
(PRKAA2)
TK
dorsomorphin
I
12
41
19
12
41
19
D
2WGJA_VGH
(MET)
TK
Crizotinib
I
21
23
55
21
23
55
D
2RFSA_AM8
(MET)
TK
SU11274
I
7
3
35
7
3
35
E
19
3G0EA_B49
(KIT)
TK
Sunitinib
I
37
40
78
E
3G0EA_B49
(KIT)
TK
Sunitinib
I
37
40
78
37
40
78
E
3G0FA_B49
(KIT)
TK
Sunitinib
I
37
40
78
37
40
78
E
2OFVA_242
(LCK)
TK
2ofv
II
28
181
65
28
181
65
E
1UWJA_BAX
(BRAF)
TK
Sorafenib
II
19
39
35
19
39
35
E
3Q96A_0NF
(BRAF)
TK
(2s)-N-[3-(2...
II
19
21
35
19
21
35
E
3QRIA_919
(ABL1)
TK
Sorafenib
II
23
18
54
23
18
54
E
3QRJA_919
(ABL1)
TK
Sorafenib
II
23
18
54
23
18
54
E
1YWNA_LIF
(KDR)
TK
AC1NS1DP
II
17
49
42
17
49
42
E
2OG8A_1N8
(LCK)
TK
1N8
II
35
190
69
35
190
69
E
1UWHA_BAX
(BRAF)
TK
Sorafenib
II
19
39
35
19
39
35
E
2OSCA_MUH
(TEK)
TK
2osc
II
17
136
36
17
136
36
E
2OO8X_RAJ
(TEK)
TK
RAJ
II
16
246
36
16
246
36
E
3BE2A_RAJ
(KDR)
TK
RAJ
II
19
249
47
19
249
47
E
3CS9A_NIL
(ABL1)
TK
Nilotinib
II
19
132
48
19
132
48
E
3C1XA_CKK
(MET)
TK
AZD_1152HQPA
II
19
77
36
19
77
36
E
3C7QA_XIN
(KDR)
TK
BIBF1120
I
25
56
50
25
56
50
E
3LQ8A_88Z
(MET)
TK
AZD_1152HQPA
II
19
71
36
19
71
36
E
2HIWA_7MP
(ABL1)
TK
2hiw
II
16
47
53
16
47
53
E
2E2BA_406
(ABL1)
TK
Bafetinib
II
18
200
48
18
200
48