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Diseases
Inhibitor-Anchor Map
Family Anchors
Kinase-Inhibitor Family
Template
Protein
Surface
Ribbon
Inhibitor
ATP Location
Pocket
ATP
NLP
HAP
CLP
SP
12 MAPK8 related diseases
hsa04930
Type II diabetes mellitus
hsa05120
Epithelial cell signaling in Helicobacter pylori infection
hsa05131
Shigellosis
hsa05132
Salmonella infection
hsa05133
Pertussis
hsa05142
Chagas disease (American trypanosomiasis)
hsa05145
Toxoplasmosis
hsa05152
Tuberculosis
hsa05160
Hepatitis C
hsa05164
Influenza A
hsa05168
Herpes simplex infection
hsa05169
Epstein-Barr virus infection
Summary of query kinase
Query kinase
MAPK8 (
P45983
)
Kinase group
CMGC
Number of conformation types
2
Number of structural templates
7 (
Total 619 inhibitors
)
Number of MAPK8 related diseases
12 (
hsa04930
hsa05120
hsa05131
hsa05132
hsa05133
hsa05142
hsa05145
hsa05152
...
)
Select
Template
Comformation
Type
No. of
Templates
Representative
Template
Kinase
Group
Representative
Inhibitor
Inhibitor
Type
No. of
Kinases
No. of
Inhibitors
No. of
Diseases
A
1
1UKIA_537
(MAPK8)
CMGC
1,9-Pyrazolo...
I
20
4
24
A
1UKIA_537
(MAPK8)
CMGC
1,9-Pyrazolo...
I
20
4
24
20
4
24
B
6
3O2MA_46A
(MAPK8)
CMGC
tetrazolylyp...
I
11
21
27
B
3O2MA_46A
(MAPK8)
CMGC
tetrazolylyp...
I
11
21
27
11
21
27
B
2NO3A_859
(MAPK8)
CMGC
4-anilinopyr...
I
4
24
17
4
24
17
B
2GMXA_877
(MAPK8)
CMGC
N-(4-AMINO-5...
I
3
29
14
3
29
14
B
2H96A_893
(MAPK8)
CMGC
5-CYANO-N-(2...
I
3
24
14
3
24
14
B
2G01A_73Q
(MAPK8)
CMGC
AC1O70UL
I
2
19
12
2
19
12
B
3ELJA_GS7
(MAPK8)
CMGC
pyrrolo[2,3-...
I
2
32
14
2
32
14